Chlorpromazine assay

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

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Details

23230B, 260112R, 424 12, 424 85, G01N 3300, A61K 3900

Patent

active

039767639

ABSTRACT:
A sensitive radioimmunoassay for chlorpromazine is described. To prepare the chlorpromazine selective antiserum, an antigen is made comprising chlorpromazine covalently bonded to an immunogenic carrier material through a diazo containing linking group and the antigen is injected into a suitable host mammal to elicit the desired antiserum. A preferred linking group is diazophenylcarbonyl while bovine serum albumin is a preferred immunogenic carrier material.

REFERENCES:
frey et al., Zentralblatt fuer Pharmazie, Pharmakotherapie und Labratorumsdiagnostic, vol. 113, No. 12, 1974, pp. 1279-1284.
Ekren et al., Nuclear Science Abstracts, vol. 28, No. 3, Aug. 15, 1973, abstract No. 6007, p. 570.
Glebov et al., Chemical Abstracts, vol. 71, No. 11, Sept. 15, 1969, abstract No. 47947v, p. 205.
Anisimor, Chemical Abstracts, vol. 68, No. 17, Apr. 22, 1968, abstract No. 76645p, p. 7387.

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