Chloropyrimidine process

Details Chloropyrimidine process Chloropyrimidine process

1998-12-18

2000-05-23

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544313, 544298, 544315, 544318, 544319, C07D23930, C07D23932, C07D23952

Patent

active

060667346

ABSTRACT:
Chloropyrimidine compounds, such as 4,6-dichloro-2-ethoxypyrimidine, were prepared in good yield and good purity from the corresponding hydroxypyrimidine compounds in the absence of organic solvents and with a reduced amount of phosphorus oxychloride by carrying out the reaction in the presence of a trialkylamine compound and phosphorus trichloride. The additions of hydroxypyrimidine compound and trialkylamine compound could be made in segments. The chloropyrimidine compounds produced were recovered in an improved manner by adding chlorine to convert the chlorophosphoric acid by-products and phosphorus trichloride to phosphorus oxychloride, diluting the mixture with additional chloropyrimidine compound and removing the phosphorus oxychloride by distillation, combining the residue with water and a base, distilling the trialkylamine compound from the resulting mixture, and removing the aqueous phase.

REFERENCES:
patent: 3845194 (1974-10-01), Somlo et al.
patent: 5057517 (1991-10-01), Johnson et al.
patent: 5525724 (1996-06-01), Hunds et al.
patent: 5563270 (1996-10-01), Schwartz et al.
patent: 5677453 (1997-10-01), Cramm et al.
patent: 5698695 (1997-12-01), Appleton et al.
patent: 5719285 (1998-02-01), Steffan
Takeda Chem. Ind., Derwent Abstracts 89-136257 (Abstracting Japanese Patent Application No. 01083071, published Mar. 28, 1989).

Affiliated with

Also associated with

Rating

Chloropyrimidine process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chloropyrimidine process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chloropyrimidine process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1837823