Chlorophyll and bacteriochlorophyll derivatives, their preparati

Details Chlorophyll and bacteriochlorophyll derivatives, their preparati Chlorophyll and bacteriochlorophyll derivatives, their preparati

1995-07-31

1997-07-22

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435106, 435117, 435119, 435197, C12P 2100, C12P 1304, C12N 918

Patent

active

056502923

ABSTRACT:
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention. The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain. The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.

REFERENCES:
Michalski et al J. Am. Chem. Soc 1988, 110, pp. 5888-5891 "Enzyme-Catalyzed Organic Synthesis: Transesterication Reactions of Chlorophyll a, Bacteriochlorophyll a and Derivatives with Chlorophyllase".

Affiliated with

Also associated with

Rating

Chlorophyll and bacteriochlorophyll derivatives, their preparati does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chlorophyll and bacteriochlorophyll derivatives, their preparati, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chlorophyll and bacteriochlorophyll derivatives, their preparati will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1559353