Chlorophyll and bacteriochlorophyll derivatives, their preparati

Details Chlorophyll and bacteriochlorophyll derivatives, their preparati Chlorophyll and bacteriochlorophyll derivatives, their preparati

1993-07-26

1998-03-10

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514410, 540145, A61K 3140, C07D48722

Patent

active

057261695

ABSTRACT:
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention. The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain. The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors.

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