Chlorination of cephalexin with chloroperoxidase from Rathayibac

Details Chlorination of cephalexin with chloroperoxidase from Rathayibac Chlorination of cephalexin with chloroperoxidase from Rathayibac

1994-12-20

1997-12-09

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435189, 43525232, C12P 3500, C12N 902, C12N 120

Patent

active

056959516

ABSTRACT:
An enzyme preparation that exhibits cephalosporin chloroperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to cefaclor in a single step. A particular, unique microorganism that can provide the cephalosporin chloroperoxidase enzyme preparation is Rathayibacter biopuresis.

REFERENCES:
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patent: 4064343 (1977-12-01), Chauvette
patent: 4316955 (1982-02-01), Abbott et al.
patent: 4672114 (1987-06-01), von Daehne
patent: 4707446 (1987-11-01), Hunter et al.
patent: 4707447 (1987-11-01), Geigert et al.
H.I. Zgurskaya et al., "Rathayibacter gen. nov., Including the Species Rathayibacter rathayi comb. nov., Rathayibacter tritici comb. nov., Rathayibacter iranicus comb. nov., and Six Strains from Annual Grasses," Int'l J. of Systematic Bacteriology 43(1): 143-149 (Jan., 1993).
M.A. Pickard et al., "Chloroperoxidase, a Peroxidase with Potential," J. of Industrial Microbiology, pp. 235-242 (1991).
M.C.R. Franssen et al., "Haloperoxidases: Their Properties and Their Use in Organic Synthesis," Advances in Applied Microbiology 37: 41-98 (1992).
Saul L. Neidleman, "Microbial Halogenation," CRC Crit. Rev. Microbiol. 5: 333-358 (1975).

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