Chloramphenicol derivatives antigens and antibodies

Details Chloramphenicol derivatives antigens and antibodies Chloramphenicol derivatives antigens and antibodies

1985-09-27

1986-08-26

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 88, 260112R, 260112B, 435 7, 435188, 436547, 436543, 530405, 530402, A61K 3900, G01N 5300

Patent

active

046082522

ABSTRACT:
Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxo-carbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.

REFERENCES:
patent: 2483884 (1949-10-01), Crooks, Jr. et al.
patent: 2483885 (1949-10-01), Crooks, Jr. et al.
patent: 2538764 (1951-01-01), Crooks, Jr. et al.
patent: 2686788 (1954-08-01), Moore et al.
patent: 3592949 (1971-07-01), Teach et al.
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 4214001 (1980-07-01), Engelhardt et al.
Hamburger et al., Chloramphenicol-Specific Antibody Reactivity to Analogs of Chloramphenicol, Immunology, 1969, V. 17, pp. 587-591.
Hamburger, Chloramphenicol-Specific Antibody, Science, 1966, V. 152, pp. 203-205.

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