Chloramphenicol derivatives, antigens and antibodies

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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424 85, 560 22, 562437, 564360, 436543, 436822, 436823, 530807, A61K 3104, A61K 3900, C07C 7946, G01N 33531

Patent

active

046082000

ABSTRACT:
Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxo-carbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.

REFERENCES:
patent: 2483885 (1949-10-01), Crooks, Jr. et al.
patent: 4489156 (1984-12-01), Khanna et al.
patent: 4489157 (1984-12-01), Khanna et al.
patent: 4496479 (1985-01-01), Hu et al.

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