Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-09-12
1982-06-01
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603975, A01N 4500, A61K 3156
Patent
active
043327974
ABSTRACT:
The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formula
REFERENCES:
patent: 4177269 (1979-12-01), Fex et al.
patent: 4181669 (1980-01-01), Hansen et al.
Journ. of Med. Chemistry, vol. 12, (1969), pp. 810-818.
Carroll et al., "Journ. of Med. Chemistry", vol. 15, No. 11, (1972), pp. 1158-1161.
Journal of Medicine Chemistry, vol. 11, No. 5, Aug. 1968, Washington, D.C., E. L. Foster et al.: "17B--(4'{p--[Bis(.beta.-chloroethyl)amino]phenyl}-butanoyloxy)-androsten- -3--one", biz. 1106.
Asano Kiro
Enomoto Satoru
Tamura Humio
Tanaka Hiromitsu
Kureha Kagaku Kogyo Kabushiki Kaisha
Roberts Elbert L.
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