Chlamydia pneumoniae polynucleotides and uses thereof

Details Chlamydia pneumoniae polynucleotides and uses thereof Chlamydia pneumoniae polynucleotides and uses thereof

2006-03-02

2009-10-13

Mondesi, Robert B (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S320100, C536S023400, C536S023700, C536S024300

Reexamination Certificate

active

07601531

ABSTRACT:
The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides ofChlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of theChlamydia pneumoniaegenome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosingChlamydia pneumoniaeinfection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particularChlamydia pneumoniae, infections.

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