Chlamydia oligosaccharides

Details Chlamydia oligosaccharides Chlamydia oligosaccharides

2006-05-30

2006-05-30

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S008100

Reexamination Certificate

active

07053067

ABSTRACT:
Oligosaccharides specific forChlamydiamediate attachment of the organism to host cells.

REFERENCES:
patent: 5132413 (1992-07-01), Aizawa et al.
patent: 0 677 295 (1995-10-01), None
patent: WO 93/05803 (1993-01-01), None
patent: WO 95/11704 (1995-04-01), None
Swanson, et al., “Identification of Lectin-binding Proteins inChlamydiaSpecies”,Infection and Immunity, Feb., 1990, vol. 58, No. 2, pp. 502-507.
Swanson, et al., “Binding of the Glycan of the Major Outer Membrane Protein ofChlamydia trachomatisto HeLa Cells”,Infection and Immunity, Jan., 1994, vol. 62, No. 1, pp. 24-28.
Kuo, et al., “An N-linked High-mannose Type Oligosaccharide, Expressed at the Major Outer Membrane Protein OfChlamydia trachomatis, Mediates Attachment and Infectivity of the Microorganism to HeLA Cells”,J. Clinical Investigation, Dec., 1996, vol. 98, No. 12, pp. 2813-2818.
Kuo, et al., “Mannose-receptor Positive and Negative Mouse Macrophages Differ in their Susceptibility to Infection byChlamydiaSpecies”,Microbial Pathogenesis, 2002, vol. 32, pp. 43-48.
Cho-chou Kuo, et al. “Cleavage of the N-Linked Oligosaccharide from the Surfaces ofChlamydiaSpecies Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells”, Infection and Immunity, Nov. 2004, vol. 72, No. 11, pp. 6699-6701.
Cho-Chou Kuo, et al. “Infectivity ofChlamydiaPneumoniae andChlamydia trachomatisis Abolished by N-Glycanase Treatment”, Department of Pathobiology, University of Washington, Seattle, WA USA; Proceedings, Fifth Meeting of the European Society forChlamydiaResearch, Budapest, Hungary, Sep. 1-4, 2004. (Editor Judith Deak) University of Szeged.
Noboru Tomiya, et al. “Analyses of N-Linked Oligosaccharides Using a Two-Dimensional Mapping Technique”, Analytical Biochemistry, vol.: 171, pp. 73-90 (1988).

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