Chitosans

Details Chitosans Chitosans

2005-05-10

2005-05-10

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S054000, C536S020000, C536S018700, C435S101000, C435S911000

Reexamination Certificate

active

06890913

ABSTRACT:
A chitosan having a weight average molecular weight of 50,000-140,000 g/mole and a degree of deacetylation of 85-95%. Also disclosed are a method of preparing a chitosan from a fungus, and a method of using a chitosan for treating breast or cervical cancer.

REFERENCES:
patent: 5232842 (1993-08-01), Park et al.
patent: 5762903 (1998-06-01), Park et al.
patent: 6255085 (2001-07-01), Chen et al.
patent: 0 183 556 (1986-06-01), None
patent: 0 531 991 (1993-03-01), None
patent: 0 730 870 (1996-09-01), None
patent: 63-246332 (1988-10-01), None
patent: 6-22725 (1994-02-01), None
patent: 7-2679 (1995-01-01), None
patent: 9-48734 (1997-02-01), None
patent: WO 0234287 (2002-05-01), None
Muhannad et al. (European Journal of Pharmaceutics and Biopharmaceutics (Jan. 2002) 53 (1) 115-23) (abstract sent).*
Hagiwara et al. (JP 01061429 A2) (abstract sent).*
Caldwell, Cytotoxic Activity of Two Polyaspartamide-based Monoamineplatinum(II) Conjugates Against the HeLa Cancer Cell Line, Applied Organometallic Chemistry 13:189-194, 1999.
Chen et al., “Inhibitory Effect of Chitosan Derived From Fungus on Tumor Cells”, JAACT/ESACT '98 Meeting, Jul. 26-30, 1998, Kyoto, Japan, P-58.
Database BIOSIS, Biosciences Information Service, Philadelphia, PA, US; PREV200200447604, 2002, XP002246933.
Database CAPLUS, Chemical Abstracts Service, Columbus, Ohio, US, retrieved from CAPLUS No. 2000:281857, XP002246881.
Eagle et al., “Cytotoxicity in Human Cell Cultures as a Primary Screen for the Detection of Anti-Tumor Agents”, Cancer Research 18: 1017-1025, 1958.
Fichera et al., “2-6-Di(heteroarylvinyl)pyridines as New Potential Antitumor Agents”, J. Phys. Org. Chem. 13:344-346, 2000.
Koide, “Chitin-Chitosan: Properties, Benefits and Risks”, Nutrition Research 18:1091-1101, 1998.
Lu et al., “Resveratrol, a Natural Product Derived From Grape, Exhibits Antiestrogenic Activity and Inhibits the Growth of Human Breast Cancer Cells”, J. of Cellular Physiology 179:297-304, 1999.
Monks et al., “Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines”, Articles 83:757-766, 1991.
Rexen et al., “Investigation of Different Modifications to the Tetrazolium Based Colorimetric Viability Assay”, Biotechnology Techniques 6:255-260, 1992.
Rogozhin et al., “The Partial Acidic Hydrolysis of Chitosan”, Polymer Science U.S.S.R. 30:607-614, 1988, XP000133818.
Sirica et al., “Selective Aggregation of L1210 Leukemia Cells by the Polycation Chitosan”, J. of the National Cancer Institute, 47:377-388, 1971.
Shahidi et al., “Food Applications of Chitin and Chitosans”, Trends in Food Science & Technology 10:37-51, 1991.
Suzuki et al., “Antitumor Effect of Hexa-N-Acetylchitohexaose and Chitohexaose”, Carbohydrate Research 151:403-408, 1986.
Tan et al., “The Degree of Deacetylation of Chitosan: Advocating the First Derivative UV-Spectrophotometry Method of Determination”, Talanta 45:713-719, 1998.
Torzsas et al., “The influence of High and Low Molecular Weight Chitosan on Colonic Cell Proliferation and Aberrant Crypt Foci Development in CF1 Mice”, Fd Chem. Toxic. 34:73-77, 1996.
Tsukada et al., “Antimetastatic and Growth-inhibitory Effects of N-Acetylchitohexaose in Mice Bearing Lewis Lung Carcinoma”, Jpn. J. Cancer Res. 81:259-265, 1990.

Affiliated with

Also associated with

Rating

Chitosans does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chitosans, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chitosans will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3388025