Chitosan induced immunopotentiation

Details Chitosan induced immunopotentiation Chitosan induced immunopotentiation

1997-03-25

1999-11-09

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4242791, 4242831, 514 23, A61K 4500, A01N 4304

Patent

active

059809124

ABSTRACT:
Methods and compositions for potentiating an immune response are disclosed which incorporate chitosan as an immunopotentiating adjuvant. Administration of the compositions of the invention is effected by various routes.

REFERENCES:
patent: 4372883 (1983-02-01), Matsuhashi et al.
patent: 4814169 (1989-03-01), Matsuhashi et al.
patent: 4971956 (1990-11-01), Suzuki et al.
patent: 5714152 (1998-02-01), Burke et al.
patent: 5716637 (1998-02-01), Anselem et al.
Edelman, R., "Vaccine Adjuvants," Rev. Infect. Dis., 2(3):370-383 (May-Jun., 1980).
Freund et al., "Sensitization and Antibody Formation after Injection of Tubercle Bacilli and Paraffin Oil," Proc. Soc. Exp. Biol. Med., 37:509-513 (1937).
Gajewski et al., "Antiproliferative Effect of IFN-.gamma. In Immune Regulation III. Differential Selection of T.sub.H 1 and T.sub.H 2 Murine Helper T Lymphocyte Clones Using Recombinant IL-2 and Recombinant IFN-.gamma.," J. Immunol., 143(1):15-22 (Jul. 1, 1989).
Gajewski et al., "Murine Th1 and Th2 Clones Proliferative Optimally in Response to Distinct Antigen-Presenting Cell Populations," J. Immunol., 146(6):1750-1758 (Mar. 15, 1991).
Gery et al., "Stimulation of B-Lymphocytes By Endotoxin: Reactions of Thymus-Deprived Mice and Karyotypic Analysis of Dividing Cells in Mice Bearing T.sub.6 T.sub.6 Thymus Grafts," J. Immunol., 108(4):1088-1091 (Apr., 1972).
Grun et al., "Different T Helper Cell Subsets Elicited in Mice Utilizing Two Different Adjuvant Vehicles: The Role of Endogenous Interleukin 1 in Proliferative Responses," Cell. Immunol., 121:134-145 (1989).
Gupta et al., "Adjuvants-A Balance Between Toxicity and Adjuvanticity," Vaccine, 11:291-306 (1993).
Harris et al., "Cloning and Characterization of Zona Pellucida Genes and cDNAs from a Variety of Mammalian Species: The ZPA, ZPB, and ZPC Gene Families, " J. Seq. and Mapping, 4:361-393 (1994).
Johnson et al., "Studies on the O Antigen of Salmonella Typhosa V. Enhancement of Antibody Response to Protein Antigens by the Purified Lipopolysaccharide," J. Exp. Med., 103:225-246 (1956).
Marcinkiewicz et al., "Immunoadjuvant Properties of Chitosan," Arch. Immunol. et Ther. Exp., 39:127-132 (1991).
Mosmann et al., "TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties," Ann. Rev. Immunol., 7:145-173 (1989).
Nishimura et al., "Immunological Activity of Chitin and Its Derivatives," Vaccine, 2:93-99 (1984).
Ramanathan et al., "Complement Activation by Aluminium and Zirconium Compounds," Immunol., 37:881-888 (1979).
Sarin et al., "Cytotoxic and Humoral Immune Responses to HIV-1 p17 Synthetic Peptide HGP-30 in Human Volunteers," Vaccine Res., 3(1):49-57 (1994).
Siskind, G., "Manipulation of the Immune Response," Pharm. Rev., 25(2):319-324 (1973).
Tomai et al., "T Cell and Interferon-.gamma. Involvement in the Adjuvant Action of a Detoxified Endotoxin," J. Biol. Resp. Mod., 8:625-643 (1989).
Warren et al., "Current Status of Immunological Adjuvants," Ann. Rev. Immunol., 4:369-388 (1986).
White et al., "Studies on the Antibody Production III. the Alum Granuloma," J. Exp. Med., 102:73-82 (1955).
Wang, G-H, Inhibition and Inactivation of Five Species of Foodborne Pathogens by Chitosan, J. Food Prot 55(11), 916-919 (1992).

Affiliated with

Also associated with

Rating

Chitosan induced immunopotentiation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chitosan induced immunopotentiation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chitosan induced immunopotentiation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1452066