Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1998-03-31
2000-05-09
Schwartzman, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, C07K 14435, C07K 14475
Patent
active
060605901
ABSTRACT:
A family of chitinase related proteins (CHRPs) that promote cell growth and may be useful in wound healing and other indications is provided. In a particular embodiment, imaginal disc growth factor 4 (IDGF4) protein and polynucleotides encoding the protein are provided. The IDGF polypeptides of the family promote cell growth when added exogenously to imaginal disc cell lines. Methods of use for members of the CHRP family, including IDGF1, IDGF2, IDGF3, IDGF4, DS47, gp38k, gp-39, Brp-39, YKL39, YKL40, POSP and homologs or orthologs thereof, are included for accelerating wound healing and tissue growth, modulating angiogenesis and ameliorating cell proliferative disorders in human patients.
REFERENCES:
Chan, C.S. et al., Clonal Rearrangement of the T-Cell Receptor Beta-Chain Gene in Hyperplastic Lymphadenopathy Associated with Lung Cancer, Cancer 68:1071-1076, 1991.
Hakala, B.E., et al., Human Cartilage gp-39, a Major Secretory Product of Articular Chondrocytes and Synovial Cells, is a Mammalian Member of a Chitinase Protein Family, J. Bio.Chem. 268: 25803-25810, 1993.
Kirkpatrick, R.B., et al., Induction and Expression of Human Cartilage Glycoprotein 39 in Rheumatoid Inflammatory and Perifpheral Blood Monocyte-Derived Macrophages, Exp.Cell Res. 237:46-54, 1997
Verheijden, G.F., et al., Human Cartilage Glycoprotein-39 as a Candidate Autoantigen in Rheumatoid Arthritis, Arthritis Rheum. 40:1115-1125, 1997.
Bryant Peter J.
Kawamura Kazuo
Haile Lisa A.
Schwartzman Robert A.
The Regents of the University of California
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