Chirally enriched synthetic phosphate oligomers

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 245, 536 253, 536 2533, 536 2534, 536 255, 536 256, 435 6, C07H 2104

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059555971

ABSTRACT:
Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.

REFERENCES:
patent: 5212295 (1993-05-01), Cook
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Vyazovkina et al., "Preparation of Trimers and Tetramers of Mixed Sequence Oligonucleoside Methylphosphonates and Assignment of Configurations ar the Chiral Phosphorus," Nucleic Acids Res., 21(25), 5957-5963 (1993).
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