Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-

Details Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy- Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-

1986-06-24

1988-07-19

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

549243, 560 28, 560 29, 560159, 564428, C07D26534

Patent

active

047586613

ABSTRACT:
(+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-o xazine is elaborated by a series of process steps that retain the enantiomeric purity of the starting material, D-aspartic acid. The product is a direct acting dopaminergic agent, useful in the treatment of Parkinson's disease.

REFERENCES:
patent: 4420480 (1983-12-01), Jones et al.
J. Org. Chem., 50, 3619, (1985), Nordlander et al.
J. Org. Chem., 46, 2431, (1981), McClure et al.
J. Org. Chem., 48, 2675, (1983), McClure et al.
J. Med. Chem., 27, 1607, (1984), Jones et al.
Eur. J. Med. Chem. Chim. Ther, 20,(3), 247-250, (1985).

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