Chiral synthesis of tertiary alcohols with a hydrolase

Details Chiral synthesis of tertiary alcohols with a hydrolase Chiral synthesis of tertiary alcohols with a hydrolase

1997-11-12

1999-06-15

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5482632, 5482634, 5482638, 5482642, 5482648, 5482652, 5482656, 5482668, 5482672, 5482674, 5482694, C07D24908, C07D24910, C07D24912, C07D24914

Patent

active

059123559

ABSTRACT:
Method of preparing an optically active compound of formula, wherein R and R.sup.1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C.sub.1 -C.sub.4 alkyl-heterocycle, each being optionally substituted, procided that R and R.sup.1 are not identical and * is an optically active chiral center, from the corresponding racemic ester or diol by treating with a hydrolase enzyme.

REFERENCES:
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patent: 5493063 (1996-02-01), Takahashi et al.
Bianchi et al., Chemoenzymatic Synthesis and Biologidal Activity of Both Enantiomeric Forms of Tetraconazole, a New Antifungal Triazole, J. Agric. Food, Chem., 1991, 39, pp. 197-201.
Bianchi, et al., Enzymatic preparation of optically active fungicide intermediates in aqueous and in organic media, Pure & Appl. Chem., 1992, vol. 64, pp. 1073-1078.
Derwent and on-line abstracts, Sagami, Japanese Patent Application 56-048888 (1981).
Janssen et al., PPL-Catalyzed Resolution of 1,2-and 1,3-Diols in Methyl Propionate as Solvent, an Application of the Tandem Use of Enzymes, Tetahedron, 1991, vol. 47, pp. 7409-7416.

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