Chiral supports for resolution of racemates

Details Chiral supports for resolution of racemates Chiral supports for resolution of racemates

1980-06-12

1982-04-13

Padgett, Benjamin R.

Compositions

Absorptive, or bindive, and chemically yieldive

210635, 210656, 210659, 252430, 252455R, 252463, 428407, 428702, B01D 1508

Patent

active

043246818

ABSTRACT:
A silylated silica or alumina covalently bonded to a chiral amino acid through a carboxyl group of said acid may be used as the solid stationary phase in the chromatographic resolution of racemic mixtures. Several classes of derivatives of such bound chiral amino acids also may be used in the resolution of racemates. Such derivatives include N-alkyl and N-acyl derivatives, and esters where the amino acid is a dicarboxylic acid or contains a hydroxy group.

REFERENCES:
patent: 4111838 (1970-09-01), Schaeffer
patent: 4159966 (1979-07-01), Roberts
Henderson et al., Nature, vol. 141 (May 21, 1938), pp. 917-918; vol. 142 (Jul. 23, 1938), pp. 162-163.
Blaschke et al., Chemische Berichte vol. 109 (1976) pp. 1967-1975.
Baczuk et al., J. of Chromatography, vol. 60 (1971) pp. 351-361.

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