Chiral stationary phases based on derivatives of...

Details Chiral stationary phases based on derivatives of... Chiral stationary phases based on derivatives of...

2006-03-28

2006-03-28

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S656000, C210S198200, C210S502100, C502S401000, C502S402000, C502S439000

Reexamination Certificate

active

07018537

ABSTRACT:
The invention describes new chiral stationary phases containing a 4-amino-3,5-dinitrobenzoic unit modified with chiral groups and spacer groups. The invention includes the process for the preparation of said stationary phases starting from 4-halogenated derivative of 3,5-dinitrobenzoic acid, chiral selectors obtainable as intermediates in the aforesaid process, and the use of the chiral stationary phases in the separation of enantiomers.

REFERENCES:
patent: 4324681 (1982-04-01), House
patent: 4963254 (1990-10-01), Oi et al.
patent: 5290440 (1994-03-01), Pirkle et al.
patent: 5487831 (1996-01-01), Pirkle et al.
patent: 0299793 (1989-01-01), None
patent: 00/00464 (2000-01-01), None
Malyshev, Journal of Chromatography, A, 859 (1999) 143-151.
Database CA Online, Chemical Abstracts Service, Columbus, Ohio, US Malyshev, O.R. et al., “Convenient synthesis of .pi.-acceptor chiral stationary phases for high-performance liquid chromatography from halogen-substituted 3,5-dinitrobenzoylamides” retrieved from STN Database accession No. 132:585521 CA, XP002203996 abstract.
Maier, N.M. et al., “Diphenylethanediamine derivatives as chiral selections V.IEfficient normal-phase high-performance liquid chromatographic enantioseparation of underivatized chiral arylalcohols on four differently linked 3,5-dinitrobenzoyldiphenylethanediamine-derived chiral stationary phases,”Journal of Chromatography A, 732, pp. 215-230 (1996).
Kontrec, D. et al., “Preparation and Evaluation of Chiral Stationary Phases Based on N,N-2,4-(or4,6)-Disubstituted 4,5-(or 2,5)-Dichloro-1,3-Dicyanobenzene,”Chirality, 12, pp. 63-70 (2000).
Pirkle, W.H. et al., “A New, Easily Accessible Reciprocal Chiral Stationary Phase fo rthe Chromatolographic Separation of Enantiomers,”J. Am. Chem. Soc.,108, pp. 352-354 (1986).
Welch, C.J., “Evolution of chiral stationary phase design in the Pirkle laboratories,”J. Chromatogr.,A 666, pp. 3-26 (1994).
Perrin, S.R. et al., “Commerically Available Brush-Type Chiral Selectors fo rthe Direct Resolution of Enantiomers,”Chiral Separations by Liquid Chromatography, American Chemical Society, pp. 43-66 (1991).
Eliel, E. L. et al., “Separation of Stereoisomers. Resolution. Racemization.”Stereochemistry of Organic Compounds, published by John Wiley & Sons, Inc., pp. 297-314.
Bayley, C.R. et al., “Resolution of Racemates by Diastereomeric Salt Formation,”Chirality in Industry, published by John Wiley & Sons Ltd., pp. 69-77 (1992).
Nógrádi, M., “Principles relating to the separation of enantiomers,”Stereochemistry Basic Concepts&Applications, Akadémiai Kiadó, Budapest, pp. 87-90 (1981).

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