Chiral stationary phase based on yohimbine

Details Chiral stationary phase based on yohimbine Chiral stationary phase based on yohimbine

1999-01-11

2000-10-17

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502401, B01D 1508

Patent

active

061326062

ABSTRACT:
A chromatographic process for separating racemic mixtures using a set of chiral stationary phases based on yohimbine and its derivatives has been developed. In particular, the hydroxyl functionality of yohimbine and its analogs is covalently bonded via a urethane linkage to a polymethylenesilyl chain attached to the bound hydroxyl groups of a refractory inorganic oxide by Si--O bonds. The resulting chiral stationary phases have multiple chiral recognition sites and can be used with a broad spectrum of materials as eluents without leaching.

REFERENCES:
patent: 5807482 (1998-09-01), House
patent: 5858910 (1999-01-01), House
Karagounis, Natuee, 142, (1938) pp. 162-163.
Giddings, Advances in Chromatography, vol. 10, Marcel Dekker New York 1974 pp. 99-172.
Baczuk, J. Chromatogr., 60, 351-361 (1971).
Blaschke, Chemische Berichte, 109, 1967-1975 (1976).
Okamoto, J. Cheomatography, 666 1994, pp. 403-419.

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