Chiral selector useful for separation of enantiomers of .beta.-a

Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

210643, 210650, 210656, B01D 6138

Patent

active

055782124

ABSTRACT:
The present invention relates to the separation of .beta.-amino alcohol compounds, particularly compounds known as .beta.-blockers, by employing what is known as a chiral selector compound which can achieve separation of enantiomers without requiring derivatization of the enantiomers before effecting separation.

REFERENCES:
patent: 4590167 (1986-05-01), Gunther et al.
patent: 5080795 (1992-01-01), Pirkle et al.
patent: 5290440 (1994-03-01), Pirkle et al.
Pirkle, et al., "A Widely Useful Chiral Stationary Phase for the High-Performance Liquid Chromatography Separation of Enantiomers", 103 J. Am. Chem. Soc., 3964-66 (1981).
Pettersson, et al., "Separation of Enantiomeric Amines by Ion-Pair Chromatography", 204 J. Chromatogr., 179-83 (1981).
Pirkle, et al., "A Rational Approach to the Design of Highly-Effective Chiral Stationary Phasers", 316 J. Chromatogr., 585-604 (1984).
Wainer, et al., "The Direct Enantiomeric Determination of (-)- (+)- Propanolol in Human Serum by High-Performance Liquid Chromatography on a Chiral Stationary Phase", 306 J. Chromatogr., 405-11 (1984).
Armstrong, et al., "Separation of Drug Stereoisomers by the Formation of B-Cyclodextrin Inclusion Complexes", 232 Science, 1132-35 (1986).
Okamoto, et al., "Optical Resolution of B-Blockers by HPLC on Cellulose Triphenylcarbamate Derivatives", Chem. Lett., 1237-40 (1986).
Pirkle, et al., "Intermolecular .sup.1 H[.sup.1 H] Nuclear Overhauser Effects in Diastereomeric Complexes: Support for a Chromatographically Derived Chiral Recognition Model", 108 J. Am. Chem. Soc., 5627-28 (1986).
Petterson, et al., "Influence of Enantiomeric Purity of Chiral Selector on Stereoselectivity", 407 J. Chromatogr., 217-29 (1987).
Pirkle, et al., "Reciprocity in Chiral Recognition Comparison of Several Chiral Stationary Phases", 404 J. Chromatogr., 107-15 (1987).
Pirkle, et al., "Systematic Studies of Chiral Recognition Mechanisms," 23-35 in Chiral Separations, Stevenson, et al., ed. (1988).
Aboul-Enein, et al., "Direct High-Performance Liquid Chromatographic Separation of Penbutolol Enantiomers on a Cellulose Tris-3, 5-dimethylyphenyl Carbamate Chiral Stationary Phase", 1 Chirality, 301-04 (1989).
Hermansson, "Enantiomeric Separation of Drugs and Related Compounds Based on their Interaction with .alpha..sub.1 -acid Glycoprotein", 8 Anal. Chem., 251-59 (1989).
Moriguchi, et al., Abstract of Paper M/TU-P-017, "Liquid Chromatographic Separation of Enantiomers Upon Chiral Stationary Phases Comprised of (D)-N-(3,5-Dinitrobenzoyl)-Penicillamine", The Thirteenth Symposium on Column Liquid Chromatography (1989).
Pirkle, et al., "Preparation of Chiral Stationary Phase From an .alpha.-Amino Phosphonate", 1 Chirality, 57-62 (1989).
Walhagen, et al., "Coupled-Column Chromatography on Imobilized Protein Phases for Direct Separation and Determination of Drug Enantiomers in Plasma", 473 J. Chromatogr., 371-79 (1989).
Erlandsson, et al., "Immobilized Cellulase (CBH I) as a Chiral Stationary Phase for Direct Resolution of Enantiomers", 112 J. Am. Chem. Soc., 4573-74 (1990).
Regis Chemical Company Catalog, Sec. 5, 42-54 (1990).
Pirkle, W. H., et al. "Chiral Stationary Phase Designed for .beta.-Blockers", 557 J. Chromatogr., 173-85 (Sep. 20, 1991).
Pirkle, W. H., et al., "A Rational Approach to the Design of Highly Effective Chiral Stationary Phases for the Liquid Chromatographic Separation of Enantiomers", 2(2) J. Pharma. Biol. Anal., 173-181 (1984).
Patent Abstracts of Japan, 15:No. 445 (C-884) and JP,A,03190827 (Nippon Steel Corp.) Aug. 20, 1991.
Pirkle et al. (1988) "An Improved Chiral Stationary Phase for the Facile Separation of Enantiomers", Journal of Chromatography vol. 144, No. 2, pp. 311-322.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chiral selector useful for separation of enantiomers of .beta.-a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chiral selector useful for separation of enantiomers of .beta.-a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chiral selector useful for separation of enantiomers of .beta.-a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1970574

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.