Chiral rhodium-diphosphine catalyst capable of catalytic reducti

Details Chiral rhodium-diphosphine catalyst capable of catalytic reducti Chiral rhodium-diphosphine catalyst capable of catalytic reducti

1978-04-14

1979-09-04

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2606065P, C07F 1500

Patent

active

041668243

ABSTRACT:
A soluble, chiral, rhodium-containing catalyst which permits the catalytic reduction of prochiral 3-acyl-1-(2-alkoxyethyl)-4-phenyl-2-imidazolinones to chiral 3-acylimidazolidinones with a substantial excess of the desired S optical isomer. The 3-acylimidazolidinones may in turn be substantially converted to levamisole, and S isomer of tetramisole. The resolution of tetramisole to remove the R isomer is thus avoided.

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H. Schmidbauer, Monatshefte fur Chemie, 96, 2058-2060, (1965).
Osborn et al., J. Chem. Soc., pp. 1711-1732, (1966).
Kosolapoff, Organic Phosphorus Compounds, Wiley Intersc., N.Y., vol. 1, pp. 480-486, (1972).
Emeleus et al., Adv. Inorg. and Radiochem. Academic Press, N.Y., vol. 14, p. 241, (1972).

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