Chiral pyridylphosphines and their application in asymmetric cat

Details Chiral pyridylphosphines and their application in asymmetric cat Chiral pyridylphosphines and their application in asymmetric cat

1997-12-10

1999-03-23

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07F 950

Patent

active

058861823

ABSTRACT:
Novel, optically active phosphorous compounds of the formula, ##STR1## wherein R.sup.1 represents hydrogen atoms, straight or branched-chain alkyl groups having from 1 to 6 carbon atoms, R.sup.2 represents hydrogen atoms, halogen atoms, lower alkyl groups (1 to 6 carbon atoms), lower alkoxy groups (1 to 6 carbon atoms), hydroxy group, chiral hydroxyalkyl groups, and amino groups (1.degree., 2.degree., 3.degree.) vinyl groups or allyl groups and R.sup.3 represents phenyl groups, aryl groups, cyclohexyl groups, substituted and unsubstituted cycloalkyl groups, heteroaromatic rings, are described. The compounds of the formula serve as highly useful ligands in the preparation of ruthenium complexes which are effective catalysts for the asymmetric hydrogenation of 2-arylpropenoic acids leading to high valued 2-arylpropionic acids.

REFERENCES:
patent: 5144050 (1992-09-01), Chan et al.
patent: 5508438 (1996-04-01), Broger
patent: 5516944 (1996-05-01), Broger
patent: 5621128 (1997-04-01), Jendralla
patent: 5710339 (1998-01-01), Laue
patent: 5789592 (1998-08-01), Gratzel
Chan, A.S.C., et al, "Synthesis of 2,2'-Bis(diphenylphosphino) . . . Acrylic Acids", J. Am. Chem. Soc., V. 102, pp. 7932-7934, 1980.
Schmid, R., et al, "102.Axially Dissymmetric . . . of N,N-Diethylnerylamine", Helvetica Chimica Acta, V. 71, pp. 897-929, 1988.
Miyashita, A., et al, "Synthesis of Atropisomeric . . . Hydrogenation of Prochiral Olefins", Chemistry Letters, pp. 1849-1852, 1989.
Schmid, R. et al, "35.Axially Dissymmetric Diphosphines in the . . . Approach", Helvetica Chimica Acta, V. 74, pp. 370-389, 1991.
Cai, D., et al, "Synthesis of Chiral 2,2'Bis(diphenylphosphino) . . . Insertion", J. Org. Chem., V. 59, pp. 7180-7181, 1994.
Kumobayashi, H., et al, "Recent Advances in Chiral Catalysis", Chiral Tech 96, 14 pages, 1996.
Ohta, T., et al, "Asymmetric Hydrogenation of Unsaturated . . . Complexes", J. Org. Chem., V. 52, pp. 3174-3176, 1987.
Khanapure, S.P., et al, "A Convenient Synthesis of . . . 3-Cyano-1-(3HO-Isobenzofuranones", Heterocycles, V. 27, pp. 2643-2651, 1988.
CA:121:255383 abs J Fluorine Chem 68(2) pp. 131-134, 1994.
CA:66:66032 abs of US3298967, Jan. 1967.
CA:1211299 abs of "Chemistry of heterocyclic compounds. 27 An improved preparation of pyridyldiphenylphosphines", J Org Chem, 43(5), pp. 947-949, 1978.

Affiliated with

Also associated with

Rating

Chiral pyridylphosphines and their application in asymmetric cat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chiral pyridylphosphines and their application in asymmetric cat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chiral pyridylphosphines and their application in asymmetric cat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2127044