Chiral polysaccharide esters, one of the methods for...

Details Chiral polysaccharide esters, one of the methods for... Chiral polysaccharide esters, one of the methods for...

2006-03-14

2006-03-14

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S124000

Reexamination Certificate

active

07012138

ABSTRACT:
The present invention relates to chiral esters of polysaccharides, preferably of cellulose, amylose, β-cyclodextrin or amylopectin, obtained by reacting, in basic medium, polysaccharides (polyhydroxylated compounds) with racemic or enriched acid chlorides bearing a hydrogen and an aromatic group on their a carbon.This acid precursor (I) may be α-phenylpropionic acid, ibuprofen, ketoprofen or naproxen and, more generally, any acid derivative which may lead to a reactive form of ketene type.These novel asymmetric esters of polyhydroxylated compounds may be used as means of chiral enrichment, as medicinal systems with sustained and controlled release of enriched chiral active principles, these active principles consisting of the acyl parts of the esters grafted onto the hydroxyls (or even onto the amines) of the polyhydroxylated compounds, or alternatively as chiral stationary phases (CSPs).The invention is also directed toward a process for preparing these esters, to a chiral enrichment process and to the enrichment means, the medicinal systems and the CSPs targeted above.

REFERENCES:
patent: 5202433 (1993-04-01), Okamoto et al.
patent: 5491223 (1996-02-01), Okamoto
patent: 0436722 (1991-07-01), None
Okamoto et al, Synlett, 1988, pp. 344-360.
Abstract of FR 1 604 123 A (1971).
Abstract of FR 2 714 671 A (1995).
Abstract of JP 52 051 095 (1977).
E. Yashima & Y. Okamoto, Bull. Chem. Soc. Jpn. ; 3289-3307 (1995).
E. Yashima et al., SYNLETT, 1998, 344-360 “Polysacharide-based chiral LC columns”.
Y. Okamoto & Y. Kaida, Journal of Chromatography A, 666 (1994), 401-419.
Rabjohn, organic Synthesis, Collective Vol. J. Wiley and Sons, 461-463, (1967).
B.S. Furniss et al., Wogel's Dexbetook of Pactice Organic Chemistry, 5 Ed., 1062-1063, (1993).
H. Van G. Elderen et al., Chirality, 6, 11-16, (1994).

Affiliated with

Also associated with

Rating

Chiral polysaccharide esters, one of the methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chiral polysaccharide esters, one of the methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chiral polysaccharide esters, one of the methods for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3610753