Chiral phosphinopyrrolidine compounds and their use for asymmetr

Details Chiral phosphinopyrrolidine compounds and their use for asymmetr Chiral phosphinopyrrolidine compounds and their use for asymmetr

1987-06-25

1989-11-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548406, 548542, 549319, 568814, 568881, 544232, 544243, 544337, 546 21, C07F 965, C07F 718, C07B 5300, B01J 3102

Patent

active

048793892

ABSTRACT:
New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom, --COR, --COOR, --CONHR or --SO.sub.2 --R where R is an alkyl or aryl group, R.sup.2 and R.sup.3 each represents independently an aryl group which may have a substituent or substituents, and R.sup.4 and R.sup.5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

REFERENCES:
patent: 4343741 (1982-08-01), Townsend
patent: 4539411 (1985-09-01), Brozer et al.
Beck et al., Chem. Abs 103, 215570s (1985).

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