Chiral phosphinopyrrolidine compounds and their use for asymmetr

Details Chiral phosphinopyrrolidine compounds and their use for asymmetr Chiral phosphinopyrrolidine compounds and their use for asymmetr

1989-03-06

1991-01-15

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564415, 568881, 585277, C07F 696518, C07B 5300, B01J 3102

Patent

active

049855670

ABSTRACT:
New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R.sup.1 is hydrogen or --COA.sup.1, --COOA.sup.2, --CONHA.sup.3, --SO.sub.2 A.sup.4 or --PO(A.sup.5).sub.2, A.sup.1, A.sup.2, A.sup.3, A.sup.4 and A.sup.5 each represents independently alkyl or aryl, R.sup.2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R.sup.3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R.sup.2 and R.sup.3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

REFERENCES:
patent: 4168381 (1979-09-01), Fischer, Jr.
patent: 4343741 (1982-08-01), Townsend
patent: 4409397 (1983-10-01), Paxton
patent: 4424312 (1984-01-01), Stille
patent: 4539411 (1985-09-01), Broger
patent: 4652657 (1987-03-01), Broger
patent: 4879389 (1989-11-01), Achiwa

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