Chiral organoiron complexes and use for assymetric reduction

Details Chiral organoiron complexes and use for assymetric reduction Chiral organoiron complexes and use for assymetric reduction

1991-06-17

1992-11-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 60, 568814, 568881, C07B 5300, C07F 1502

Patent

active

051663490

ABSTRACT:
##STR1## Compounds having general formula (I) wherein (i) Cp is either a cyclopentadienyl ligand having the formula C.sub.5 (R.sup.3).sub.5 where the R.sup.3 groups are independently hydrogen, methyl or ethyl or an indenyl ligand; (ii) Z is a ligand having the formula X(R.sup.4).sub.2 (Y) wherein X is selected from phosphorus, arsenic or antimony; the R.sup.4 groups are independently aryl or aroxy and Y is selected from --R.sup.5 --NHR.sup.5 and --OR.sup.5 wherein R.sup.5 is a hydrocarbyl group; (iii) the R groups are independently hydrogen, halogen or C.sub.1 to C.sub.4 alkyl; (iv) R.sup.1 is selected from hydrogen, C.sub.1 to C.sub.6 alkyl, benzyl and --CO.sub.2 R.sup.6 where R.sup.6 is C.sub.1 to C.sub.6 alkyl; (v) R.sup.2 is selected from hydrogen, C.sub.1 to C.sub.10 alkyl, phenyl and benzyl, and (vi) B is either R or COY wherein Y is selected from --NHR.sup.7, --OR.sup.7 and --SR.sup.7 where R.sup.7 is a hydrocarbyl group is provided. The compounds are efficient asymmetric hydrogenating agents for prochiral carbonyl containing compounds when used in single enantiomer form.

REFERENCES:
Brunner et al, Jour. of Organometallic Chem., vol. 210, No. 2, 1981, pp. 223-236.
Nakamura et al, Tetrahedron Letters, No. 48, 1978, Pergamon Press, pp. 4815-4818.
Davies et al, Tetrahedron Letters, vol. 11, No. 22, 1990 Pergamon Press, pp. 3213-3216.

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