Chiral mobile phase additives for improved liquid-chromatography

Details Chiral mobile phase additives for improved liquid-chromatography Chiral mobile phase additives for improved liquid-chromatography

1992-08-27

1994-08-16

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 2101982, 95 82, 95 88, 96101, B01D 1508

Patent

active

053384547

ABSTRACT:
Chromatographic separations and resolutions of racemic mixtures and diastereoisomers are enhanced by simultaneously employing an enantiomeric, chiral stationary phase (CSP) and an enantiomeric, chiral mobile phase additive (CMPA) bearing a stereoisomeric relationship to the CSP but having the opposite chirality are enhanced relative to the use of either a CSP or a CMPA alone. Specific CMPA compositions having the structural formulas ##STR1## are also disclosed.

REFERENCES:
patent: 4290893 (1981-09-01), Hare
M. Fujita, et al., "Highly Efficient Chromatographic Resolution of Co(en)313+Ion with a Column of TA(ES) Sephadex Containing D-Tartrate Groups", Chem. Lett., Chem. Soc. Japan (1975) pp. 473-474.
C. Pettersson and C. Gioeli, J. Chrom. 435 (1988) pp. 225-228, "Improved Resolution of Enantiomers of Naproxen By The Simultaneous Use of a Chiral Stationary Phase and a Chiral Additive in the Mobile Phase".

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