Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus containing
Reexamination Certificate
2011-08-30
2011-08-30
Witherspoon, Sikarl (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus containing
C556S021000, C560S190000, C502S162000, C502S166000, C502S167000
Reexamination Certificate
active
08008529
ABSTRACT:
Ligands of the formula (I) secondary phosphine-Q-P(═O)HR1(I) in the form of mixtures of diastereomers or pure diastereomers, in which secondary phosphine is a secondary phosphine group with hydrocarbon radicals or heterohydrocarbon radicals as substituents; Q is a bivalent bisaryl or bisheteroaryl radical with an axial chiral centre to which the two phosphorus atoms are bonded in the ortho positions to the bisaryl or bisheteroaryl bridge bond, or Q is a bivalent ferrocenyl radical with a planar chiral centre or without a planar chiral centre, to which the phosphorus atom of the secondary phosphine is bonded directly or via a C1-C4-carbon chain to a cyclopentadienyl ring, the —P*(═O)HR1group is bonded either on the same cyclopentadienyl ring in ortho position to the bonded secondary phosphine or on the other cyclopentadienyl ring; P* is a chiral phosphorus atom, and R1is a hydrocarbon radical, a heterohydrocarbon radical or a ferrocenyl radical, where R1is a ferrocenyl radical with a planar chiral centre when Q is a ferrocenyl radical without a planar chiral centre. Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
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Feng Xiangdong
Pfaltz Andreas
Pugin Benoît
Ramalingam Balamurugan
Ribourdouille Yann
Solvias AG
Wenderoth , Lind & Ponack, L.L.P.
Witherspoon Sikarl
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