Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing
Reexamination Certificate
2006-05-16
2006-05-16
Witherspoon, Sikarl A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfur containing
C568S023000, C514S707000, C514S708000
Reexamination Certificate
active
07045663
ABSTRACT:
The invention provides enantiomers of ajoene and derivtives of Z(−)-ajoene. The derivative of Z(−)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.
REFERENCES:
patent: 4126676 (1978-11-01), Sanders
patent: 4239778 (1980-12-01), Venton et al.
patent: 4274410 (1981-06-01), Chvapil
patent: 4341762 (1982-07-01), Haast
patent: 4643994 (1987-02-01), Block et al.
patent: 4665088 (1987-05-01), Apitz-Castro et al.
patent: 4876281 (1989-10-01), Yoshida et al.
patent: 5066658 (1991-11-01), Demers et al.
patent: 5093122 (1992-03-01), Kodera
patent: 5279941 (1994-01-01), Lessey
patent: 5380646 (1995-01-01), Knight et al.
patent: 5464855 (1995-11-01), Capiris et al.
patent: 5478725 (1995-12-01), Lessey
patent: 5731288 (1998-03-01), Markland, Jr. et al.
patent: 5856363 (1999-01-01), Tatarintsev et al.
patent: 5863954 (1999-01-01), Tatarintsev et al.
patent: 5863955 (1999-01-01), Tatarintsev et al.
patent: 5932621 (1999-08-01), Tatarintsev
patent: 5948821 (1999-09-01), Tatarintsev et al.
patent: 5968988 (1999-10-01), Tatarintsev
patent: 5981602 (1999-11-01), Tatarintsev et al.
patent: 6177475 (2001-01-01), Tatarintsev et al.
patent: 153881 (1985-09-01), None
patent: 185324 (1986-06-01), None
patent: WO 94/15953 (1994-07-01), None
Block et al. Antithrombotic Organosulfur Compounds from Garlic: Structural, Mechanistic, and Synthetic Studies. Journal of the American Chemical Society, 1986, vol. 108, p 7045-7055.
Int'l Search Report for PCT/US01/21826, Oct. 30, 2001, Davidson.
Perbec, L.; Hedqvist, P “Prostaglandins E1And E2Antagonize Indomethacin-Induced Decrease In Survival Rate Of Haemorrhagically Shocked Rats,”Acta Chir Scand., suppl.1980, 500, 91-94.
Bourinbaiar, A. S.; Nagomy, R. “Human Immunodeficiency Virus Type 1 Infection of Choriocarcinoma-Derived Trophoblasts,”Acta. Virol., 1993, 37, 21-28.
Liu, D. Y.; Kaymakcalan, Z. “In Vitro Adgesion Assay,” Adhesion: Its Role in Inflammatory Disease, (Harlan, J. M.; Liu, D. Y. eds., W.H. Freeman and Company 1992),Appendix, 189-193.
Harlan, J. M.; Winn, R. K.; Vedder, N . B.; Doerschuk, C. M.; Rice, C. L. “In Vivo Models Of Leukocyte Adherence To Endothelium,” Adhesion: Its Role in Inflammatory Disease, (Harlan, J. M.; Liu, D. Y. eds., W.H. Freeman and Company 1992),Chapter 6, 117-150.
Liu, D. Y.; Harlan, J. M. “Outlook For The Future,” Adhesion: Its Role In Inflammatory Disease, (Harlan, J. M.; Liu, D. Y. eds., W.H. Freeman and Company 1992),Chapter 8, 183-187.
Levy, J. A. “Viral and Cellular Factors Influencing HIV Tropism,” Mechansims and Specificity of HIV Entry into Host Cells, (Dü{umlaut over ( )}zgünes, N. ed., Plenum Press 1991), 1-15.
Meyers, K. M. “Pathobiology of Animal Platelets,”Adv. Vet. Sci. Comp. Med., 1985, 30, 131-165.
Phillips D. M. “The Role of Cell-to-Cell Transmission in HIV Infection,”AIDS, 1994, 8, 719-731.
Johnson, V. A. “New Developments In Antiretroviral Drug Therapy for HIV Infection,”AIDS Clinical Review, 1992, 70-104.
Stevenson, M.; Bukrinsky, M.; Haggerty, S. “HIV-1 Replication and Potential Targets for Intervention,”AIDS Res. and Human Retrovir., 1992, 8, 107-117.
Butera, S. T.; Folks, T. M. “Application of Latent HIV-1 Infected Cellular Models to Therapeutic Intervention,”AIDS Res. and Human Retrovir., 1992, 8, 991-995.
Kolson, D. L.; Buchhalter, J.; Collman, R.; Hellmig, B.; Farrell, C. F.; Debouck, C.; Gonzalez-Scarano, F. “HIV-1 Tat Alters Normal Organization of Neurons and Astrocytes in Primary Rodent Brain Cell Cultures: RGD Sequence Dependence,”AIDS Res. and Retrovir., 1993, 9, 677-685.
Guo, M. M. L.; Hildreth J. E. K. “HIV Acquires Functional Adhesion Receptors from Host Cells,”Aids Research And Human Retroviruses, 1995, 11, 1007-1013.
Hsueh, W.; Gonzalez-Crussi, F.; Arroyave, J. L. “Platelet-Activating Factor-Induced Ischemic Bowel Necrosis,”AJP, 1986, 122, 231-239.
Acosta, E. P.; Fletcher, C. V. “Agents for Treating Human Immunodeficiency Virus Infection,”Am. J. Hosp. Pharm., 1994, 51, 2251-2267.
Zutter, M. M.; Mazoujian, G.; Santoro, S. A. “Decreased Expression Of Integrin Adhesive Protein Receptors In Adenocarcinoma Of The Breast,”American Journal Of Pathology, 1990, 137, 863-870.
Feuerstein, G.; Hallenbeck, J. M. “Prostaglandins, Leukotrienes, and Platelet-Activating Factor in Shock,”Am. Rev. Pharmacol. Toxicol., 1987, 27, 301-313.
Bone, Roger C. “The Pathogenesis of Sepsis,”Annals of Internal Medicine, 1991, 115, 457-469.
Henderson, W. R. “The Role of Leukotrienes in Inflammation,”Ann. Intern. Med., 1994, 121, 684-697.
Mueller, B. M.; Reisfeld, R. A.; Silveira, M. H.; Duncan, J. D.; Wrasidlo, W. A. “Pre-Clinical Therapy of Human Melanoma with Melanoma with Morpholino-Doxorubicin Conjugated to a Monoclonal Antibody Directed Against an Integrin on Melanoma Cells,”Antibody, Immunoconjugates, and Radiopharmaceuticals, 1991, 4, 99-106.
Tadi, P. P.; Lau, B. H. S.; Teel, R. W.; Hermann, C. F. “Binding of Aflatoxin B1to DNA by Ajoene and Diallyl Sulfide,”Anticancer Research, 1991, 11, 2037-2042.
Chambers, A. F.; Behrend, E. I.; Wilson, S. M.; Denhardt, D. T. “Induction of Expression of Osteopontin (OPN; Secreted Phosphoprotein) in Metastatic, Ras-Transformed, NIH 3T3 Cells,”Anticancer Research, 1992, 12, 43-48.
Delaha, E. C.; Garagusi, V. F. “Inhibition of Mycobacteria by Garlic Extract (Allum sativum),”Antimicrob. Agents Chemother., 1985, 27, 485-486.
San-Blas, G.; San-Blas, F.; Gil, F.; Marino, L.; Apitz-Castro, R. “Inhibition of Growth of the Dimorphic FungusParacoccidioides brasiliensisby Ajoene,”Antimicrobial Agents and Chemotherapy, 1989, 33, 1641-44.
Perez, H. A.; De La Rosa, M.; Apitz, R. “In Vivo Activity of Ajoene against Rodent Malaria,”Antimicrobial Agents and Chemotherapy, 1994, 38, 337-339.
Bridges, C. G.; Brennan, T. M.; Taylor, D. L.; McPherson, M.; Tyms, A. S. “The Prevention of Cell Adhesion and the Cell-to-Cell spread of HIV-1 In Vitro by the α-glucosidase 1 Inhibitor, 6-οbutanoyl Castanospermine (MDL 28574),”Antiviral Research, 1994, 25, 169-175.
Yoshida, S.; Kasuga, S.; Hayashi, N.; Ushiroguchi, T.; Matsuura, H.; Nakagawa, S. “Antifungal Activity of Ajoene Derived from Garlic,”Applied and Environmental Microbiology, 1987, 53, 615-17.
Nock, L. P.; Mazelis, M. “The C-S Lyases of Higher Plants: Preparation and Properties of Homogeneous Alliim Lyase from Garlic (Allium sativum),”Archives of Biochemistry and Biophysics, 1986, 249, 27-33.
Hite, L. A.; Jia, L-G.; Bjamason, J. B.; Fox, J. W. “cDNA Sequences for Four Snake Venom Metalloproteinases: Structure, Classification, and Their Relationship to Mammalian Reproductive Proteins,”Archives of Biochemistry and Biophysics, 1994, 308, 182-191.
Kavanaugh, A. F.; Davis, L. S.; Nichols, L. A.; Norris, S. H.; Rothlein, R. Scharschmidt, L. A.; Lipsky P. E. “Treatment of Refractory Rheumatoid Arthritis With a Monoclonal Antibody to Intercellular Adhesion Molecule 1,”Arthritis&Rheumatism, 1994, 37, 992-999.
Oelkers, B.; Diehl, H.; Liebig, H. “In Vitro Inhibition of Cytochrome P-450 Reductases from Pig Liver Microsomes by Garlic Extracts,”Arzneim.-Forsch/Drug Res., 1992, 42, 136-39.
Bordia, A. “Effect of Garlic on Human Platelet Aggregation In Vitro,”Atherosclerosis, 1978, 30, 355-60.
Bachelot, C.; Cano, E.; Grelac, F.; Saleun, S.; Druker, B. J.; Levy-Toledano, S.; Fischer, S.; Rendu, F. “Functional Implications of Tyrosine Protein Phosphorylation in Platelets,”Biochem J., 1992, 284, 923-28.
Huang, T-F.; Sheu, J-R.; Teng, C-M. “A Potent Antiplatelet Peptide, Triflavin,
Davidson John B.
Hildreth James K.
Tatarintsev Alexander V.
Turgiev Ali S.
Billings Pharmaceuticals, Inc.
Witherspoon Sikarl A.
Zayia Gregory H.
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