Chiral glycerol derivatives

Details Chiral glycerol derivatives Chiral glycerol derivatives

1994-07-25

1997-08-19

Kight, III, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536120, 536124, 536125, C07H 100, C07H 1502, C07H 1504, C07H 1520

Patent

active

056590210

ABSTRACT:
Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.

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Chemical Abstracts, vol. 76, No. 7, Issued 14 Feb. 1972, Ciba-Geigy "Antiinflammatory D-Glucofuranose Compounds" see p. 345, col. 2, Abstract No. 345360p, Brit. 1,246,117 (cl. C07D, A61K), 15 Sep. 1971, Swiss Appl. 11 Sep. 1967-25 Apr. 1968.
Chemical Abstracts, vol. 109, No. 5, Issued 1 Aug. 1988, Martin "Intramolecular C-Arylation of 2,3,5-tri-O-Benzyl and 2,3,5-tri-O-(3-Methylbenzyl) Pentofuranose Derivatives" see p. 644, col. 1, Abstract No. 38092p, Carbohydr. Res. 1987, 171, 211-22 (Eng).

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