Chiral glycerol derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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536 11, 544277, 558169, C07D31720, C07D31722

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active

049315757

ABSTRACT:
Enantiomerically pure glycerol derivatives, e.g. S-1,2-O-isopropylidene, S-1,2-O-benzylidene, and R-1,2-O-dibenzyl glycerol, have been prepared from 1,2R-O-protected erythritols in high yields. The latter compounds are easily obtained from erythorbic acid and are useful building blocks in the synthesis of a host of optically active compounds having biological activity.

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Dondoni, et al., "Synthesis of Long Chain Sugars by Iterative, Diastereoselective Homologation of 2,3-O-Isopropylidene-D-glyceraldehyde with 2-Trimethylsilylthiazole", Angew. Chem. Int. Ed. Engl., 25, pp. 835-837 (1986).
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Barker et al., Chem. Abs., 59, 8841h.
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Sviridov, et al., Chem. Abs., 98, 179766c (1983).
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