Chiral diols, their manufacture and ligands and catalysts...

Details Chiral diols, their manufacture and ligands and catalysts... Chiral diols, their manufacture and ligands and catalysts...

2003-09-23

2008-12-16

Price, Elvis O (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S715000, C568S807000, C568S808000, C568S009000, C568S012000, C568S017000

Reexamination Certificate

active

07465838

ABSTRACT:
The present invention relates to a method for the preparation of C2-symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R1and R2have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C2-symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

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