Chiral cyanohydrination process

Details Chiral cyanohydrination process Chiral cyanohydrination process

1985-06-26

1986-09-09

Torrence, Dolph H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

549 58, 549 75, 549426, 549491, C07C12175

Patent

active

046110763

ABSTRACT:
Chiral aromatic cyanohydrins are prepared by treating an aromatic aldehyde with cyanide ions in the presence of an inert, aprotic solvent and a chiral cyclo(phenylalanyl-histidine) and an alcohol. The technique is especially useful for reducing the induction period when starting-up the process, increase the rate of reaction and to produce a product of increased enantiomeric selectivity.

REFERENCES:
Oku, J. et al., J.C.S. Chem. Comm., pp. 229-230 (1981).
Oku, J. et al., Makromol. Chem., 183, pp. 579-586 (1982).
Oku, J., Kagaku Kogyo, 32 (11), pp. 1134-1136 (62-64), Nov. 1981 and translation.

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