Chiral copolymers with oligosiloxane spacers

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From silicon reactant having at least one...

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528 26, 528 28, 528 29, 528 30, 528 31, 556419, 556450, C08G 7704

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052684423

ABSTRACT:
Chiral copolymers containing chiral molecular grooves or cavities and oligosiloxane spacers are disclosed. The chiral portion of the copolymer is an enantiomerically enriched organic grouping, having physical properties attributed to uniform and stereochemically possible molecular grooves or cavities, which is chemically and thermally stable to gas, liquid or supercritical s fluid chromatographic conditions and is configured such that one enantiomer of an enantiomeric mixture will be better able to preferentially enter such groove or cavity and interact more strongly than other enantiomers in said mixture. The chiral grouping will contain one Or more combinations of organic moieties selected from the group consisting of methylene, phenylene, naphthylene, biphenylene, binaphthylene, a cyclodextrin and cycloalkylydene and substituted derivatives thereof and also includes non-metal atoms and functional groups which act as linking agents for the organic chiral cavity-containing moieties which are selected from the group consisting of ethers, thioethers, amines, carbonyls, amides, esters, sulfoxides, sulfonates, thioamides, thioesters, ureas, thioureas, carbamates, thiocarbamates, phosphines and phosphine oxides. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.

REFERENCES:
patent: 4387206 (1983-06-01), Bayer et al.
patent: 4997965 (1991-03-01), Lohmann et al.

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