Chiral compounds and their resolution synthesis using enantiosel

Details Chiral compounds and their resolution synthesis using enantiosel Chiral compounds and their resolution synthesis using enantiosel

1995-05-30

1997-08-26

Springer, David B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435120, 435121, 435128, 435280, 546250, C12P 1712, C12P 1714, C12P 1710

Patent

active

056610149

ABSTRACT:
Enantiomeric glutarimides such as aminoglutethimide and rogletimide are prepared by cyclisation of a corresponding ester-nitrile which is a good substrate for biotransformation with an enantiospecific esterase.

REFERENCES:
G. Ramos et al., "Application of Microbes and Microbial Esterases to the Preparation of Optically Active N-Acetylindoline-2-Carboxylic Acid", Agric. Biol. Chem. 51(7): 1833-1838 (1987).
R. McCague et al., "Synthesis of the Aromatase Inhibitor 3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione and its Enantiomers", J. Chem. Soc. Perkin Trans. I pp. 196-198 (1989).
A. Boss et al., "A Concise Synthesis of Racemic Pyridoglutethimide and its Resolution Using Chiral Stationary Phase HPLC", Tetrahedron 45(18): 6011-6016 (1989).

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