Chimeric viral receptor polypeptides

Details Chimeric viral receptor polypeptides Chimeric viral receptor polypeptides

1993-10-07

1998-11-10

Ziska, Suzanne E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303873, 5303883, 5303891, 530826, 4351713, C12N 1500, C12P 2108, C07K 1600, C07K 1400

Patent

active

058345892

ABSTRACT:
Target cell specificity of delivery vectors is provided by incorporation of a target cell specific binding domain by the use of any binding domain, which binds specifically to a binding site on the target cell. The binding site may be endogenous to the target cell, provided by engineering the target cell, or a suitable binding site may be associated with the target cell. Target cells may also be associated with a CVR polypeptide to provide specificity for the delivery vector. The association of the CVR polypeptide confers target cell specificity for a second virus host cell range, which specificity differs from the viral host cell range of the endogenous target cell or animal host cell viral receptors. The CVR polypeptide may thus comprise a chimeric virus binding site which binds a second virus env binding domain specific for a second virus host cell range, selected from at least one of the group consisting of amphotropic, polytropic, xenotropic, ecotropic and tissue specific.

REFERENCES:
Etienne-Julan et al. BMT 9 (SI): 139, 1992.
Albritton et al. Cue 57: 659, 1989.
Cunningham et al. Science 243: 1330, 1989.
Bunhman et al. PNAS 88: 8616, 1991.

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