Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-01-21
2008-11-11
Kelly, Robert M. (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024200, C514S04400A, C424S093100, C424S093210, C435S320100
Reexamination Certificate
active
07449565
ABSTRACT:
The present invention relates to chimeric molecules comprising portions of rat PEG-3 (“rPEG-3”) and human GADD34 (“hGADD34”) having apoptotic activity. It is based, at least in part, on the discovery that a chimeric protein comprising amino acids 1-347 of rat PEG-3 fused with residues 418-674 of human GADD34 exhibited anti-proliferative activity when expressed in transformed cells. The present invention provides for this and other rPEG3/hGADD34 chimeras, and the use of such proteins in inhibiting cell proliferation, angiogenesis, and tumor growth.
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Baker & Botts LLP
Kelly Robert M.
The Trustees of Columbia University in the City of New York
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