Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-09-11
2007-09-11
Whiteman, Brian (Department: 1635)
Chemistry: molecular biology and microbiology
Vector, per se
Reexamination Certificate
active
10110681
ABSTRACT:
Disclosed are compositions and methods for achieving successful treatment of disorders of the human prostate. In preferred embodiments, methods and compositions are provided that improve the specificity and safety of gene delivery vectors, and improve the prostate-specificity and activity of genetic constructs targeted for prostate-specific expression. Also disclosed are methods utilizing a variety of therapeutic genes, including those encoding tumor-specific therapeutics, e.g., TRAIL, tumor suppressors, cytotoxins, and the like, for the treatment of proliferative disorders of the prostate, and in particular, prostatic hyperplasia, prostate cancer and prostatic tumors. In preferred embodiments genetic constructs are disclosed comprising one or more prostate-specific chimeric enhancer elements in combination with one or more wildtype core enhancer elements and a prostate-specific proximal promoter that increase expression of selected heterologous genes operably positioned under their control.
REFERENCES:
patent: 5698443 (1997-12-01), Henderson et al.
patent: 5830686 (1998-11-01), Henderson
patent: 5871726 (1999-02-01), Henderson et al.
patent: 6051417 (2000-04-01), Henderson et al.
patent: 6057299 (2000-05-01), Henderson
patent: 6110702 (2000-08-01), Pang et al.
patent: 6120994 (2000-09-01), Tam
patent: WO95/19434 (1995-07-01), None
patent: WO96/14875 (1996-05-01), None
patent: WO97/01358 (1997-01-01), None
Cleutjens et al., Molecular Endocrinology 11:148-161, 1997.
Pang, Shen, et al.,Identification of a Positive Regulatory Element Responsible for Tissue-specific Expression of Prostate-specific Antigen, Cancer Research, vol. 57, pp. 495-499, Feb. 1, 1997.
Riegman, P.H.J., et al.,The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element, Molecular Endocrinology, vol. 5, No. 12, pp. 1921-1930 (1991).
Zhang, S., et al.Defining a Functional Androgen Responsive Element in the 5′ Far Upstream Flanking Region of the Prostate-Specific Antigen Gene, Biochemical and Biophysical Research Communications, No. 231, pp. 784-788 (1997).
Huang, Weibiao, et al.,Cooperative Assembly of Androgen Receptor into a Nucleoprotein Complex that Regulates the Prostate-specific Antigen Enhancer, Journal of Biological Chemistry, vol. 274, No. 36, pp. 25756-25768 (1999).
Bacchetti, S. et al., “Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA,”PNAS USA, 74:1590-1594 (1977).
Carey, M., “The Enhanceosome and Transcriptional Synergy,”Cell, 92:5-8 (1998).
Cleutjens, K. et al., “Two Androgen Response Regions Cooperate in Steroid Hormone Regulated Activity of the Prostate-specific Antigen Promoter,”J. Biol. Chem., 271:6379-6388 (1996).
Cleutjens, K. et al., “A 6-kb Promoter Fragment Mimics in Transgenic Mice the Prostate-Specific and Androgen-Regulated Expression of the Endogenous Prostate-Specific Antigen Gene in Humans,”Mol. Endocrinol., 11:1256-1265 (1997).
Dannull, J. et al., “Development of gene therapy for prostate cancer using a novel promoter of prostate-specific antigen,”British J. of Urol., 79:97-103 (1997).
El-Shirbiny, A.M., “Prostate Specific Antigen,”Adv. Clin. Chem., 31;99-133 (1994).
Gotoh, A. et al., “Development of Prostate-Specific Antigen Promoter-Based Gene Therapy for Androgen-Independent Human Prostate Cancer,”J. of Urol., 160:220-229 (1998).
Herman, J.R. et al., “In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial,”Human Gene Therapy, 10:1239-1249 (1999).
Kasper, S. et al., “Cooperative Binding of Androgen Receptors to Two DNA Sequences is Required for Androgen Induction of the Probasin Gene,”J. of Biol. Chem., 269:31763-31769 (1994).
Kay, A.B. et al., “Messenger RNA Expression of the Cytokine Gene Cluster, Interleukin 3 (IL-3), IL-4, IL5, and Granulocyte/Macrophage Colony-stimulating Factor, in Allergen-induced Late-hase Cutaneous Reactions in Atopic Subjects,”J. Exp. Med.,173:775-778 (1991).
Li, Y. et al., “Proinflammatory Cytokines Tumor Necrosis Factor-α And IL-6, But Not IL-1, Down-Regulate The Osteocalcin Gene Promoter,”J. of Immun., 148:788-794 (1992).
Lu, Y. et al., “Delivery of adenoviral vectors to the prostate for gene therapy,”Cancer Gene Therapy, 6:64-72 (1999).
Pang, S. et al., “Prostate Tissue Specificity of the Prostate-Specific Antigen Promoter Isolated from a Patient with Prostate Cancer,”Human Gene Therapy, 6:1417-1426 (1995).
Scheller, A. et al., “Multiple Receptor Domains Interact to Permit, or Restrict, Androgen-specific Gene Activation,”J. of Biol. Chem., 273:24216-24222 (1998).
Schuur, E.R. et al., “Prostate-specific Antigen Expression Is Regulated by an Upstream Enhancer,”J. of Biol. Chem., 271:7043-7051 (1996).
Steiner, M.S. et al., “In vivo expression of prostate-specific adenoviral vectors in a canine model,”Cancer Gene Therapy, 6:456-464 (1999).
Vile, R.G. et al., “Systemic Gene Therapy of Murine Melanoma Using Tissue Specific Expression of the HSVtk Gene Involves an Immune Component,”Cancer Research, 54:6228-6234 (1994).
Wei, C. et al., “Tissue-specific expression of the human prostate-specific antigen gene in transgenic mice: Implications for tolerance and immunotherapy,”Proc. Natl. Acad. Sci. USA, 94:6369-6374 (1997).
Zhang, J. et al., “Identification of two novel cis-elements in the promoter of the prostate-specific antigen gene that are required to enhance androgen receptor-mediated transactivation,”Nucleic Acids Research, 25:3143-3150 (1997).
Belldegrun Arie S.
Carey Michael F.
Wu Lilly
The Regents of the University of California
Townsend and Townsend / and Crew LLP
Whiteman Brian
LandOfFree
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