Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-10-24
2010-12-07
Ulm, John D (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069700, C530S350000
Reexamination Certificate
active
07847080
ABSTRACT:
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
REFERENCES:
patent: 5993778 (1999-11-01), Firestein et al.
patent: 6383778 (2002-05-01), Zucker et al.
patent: 6540978 (2003-04-01), Margolskee et al.
patent: 6955887 (2005-10-01), Adler et al.
patent: 7022488 (2006-04-01), Servant et al.
patent: 7208290 (2007-04-01), Li et al.
patent: 7223551 (2007-05-01), Adler et al.
patent: 7241880 (2007-07-01), Adler et al.
patent: 7244584 (2007-07-01), Zucker et al.
patent: 7244835 (2007-07-01), Adler et al.
patent: 7294474 (2007-11-01), Zoller et al.
patent: 7297543 (2007-11-01), Zoller et al.
patent: 7297772 (2007-11-01), Zoller et al.
patent: 7301009 (2007-11-01), Zoller et al.
patent: 7303886 (2007-12-01), Zoller et al.
patent: 7309577 (2007-12-01), Zoller et al.
patent: 7344859 (2008-03-01), Zoller et al.
patent: 7364903 (2008-04-01), Zoller et al.
patent: 7368285 (2008-05-01), Zoller et al.
patent: 7419791 (2008-09-01), Adler et al.
patent: 7435552 (2008-10-01), Adler et al.
patent: 7452685 (2008-11-01), Adler et al.
patent: 7465550 (2008-12-01), Zuker et al.
patent: 7507544 (2009-03-01), Adler et al.
patent: 2002/0051997 (2002-05-01), Zuker et al.
patent: 2002/0094551 (2002-07-01), Adler
patent: 2002/0151052 (2002-10-01), Chaudhari et al.
patent: 2002/0160424 (2002-10-01), Adler et al.
patent: 2002/0168635 (2002-11-01), Zuker et al.
patent: 2003/0008344 (2003-01-01), Adler et al.
patent: 2003/0022278 (2003-01-01), Zuker et al.
patent: 2003/0022288 (2003-01-01), Zuker et al.
patent: 2003/0036089 (2003-02-01), Wei et al.
patent: 2003/0040045 (2003-02-01), Zuker et al.
patent: 2003/0054448 (2003-03-01), Adler et al.
patent: 2003/0166137 (2003-09-01), Zuker et al.
patent: 2003/0232407 (2003-12-01), Zoller et al.
patent: 2004/0086877 (2004-05-01), Lal et al.
patent: 2005/0106571 (2005-05-01), Erlenbach et al.
patent: 2007/0105159 (2007-05-01), Erlenbach et al.
patent: 95/08627 (1995-03-01), None
patent: 00/06592 (2000-02-01), None
patent: 00/06593 (2000-02-01), None
patent: 01/64882 (2001-09-01), None
patent: 01/66563 (2001-09-01), None
patent: 01/83749 (2001-11-01), None
patent: 03/025137 (2002-03-01), None
patent: 02/064631 (2002-08-01), None
patent: 03/001876 (2003-01-01), None
patent: 2005/015158 (2005-02-01), None
Guo, et al., “Protein Tolerance to Random Amino Acid change”, PNAS, vol. 101, No. 25, p. 9205-9210, Jun. 22, 2004.
Nelson,et al., “An Amino-acid Taste Receptor”, Nature, vol. 416, p. 199-202, Mar. 14, 2002.
Li, et al., “Human Receptors for Sweet and Umami Taste”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, vol. 99, No. 7, Apr. 2, 2002, pp. 4692-4696—XP002254830.
Waterston, R.H., “Direct Submission”, Genome Sequencing Center, Apr. 21, 2000—XP002262036.
Adler, et al., “A Novel Family of Mammalian Taste Receptors”, Cell, vol. 100, pp. 693-702, Mar. 17, 2000-XP—000982304.
Montmayeur, et al., “A Candidate Taste Receptor Gene Near a Sweet Taste Locus,” Nature Neuroscience, May 2001, pp. 492-498, vol. 4, No. 5, Nature America, Inc., US.
Kitagawa, et al., “Molecular Genetic Identification of a Candidate Receptor Gene for Sweet Taste,” Biochemical and Biophysical Research Communications, Apr. 27, 2001, pp. 236-242, vol. 283, No. 1, Academic Press, San Diego, California, US.
Max, et al., “Tas1r3, Encoding a New Candidate Taste Receptor, is Allelic to the Sweet Responsiveness Locus Sac,” Nature Genetics, May 2001, pp. 58-63, vol. 28, No. 1, Nature America, New York, US.
Sainz, et al., “Identification of a Novel Member of the T1R Family of Putative Taste Receptors,” Journal of Neurochemistry, May 2001, pp. 896-903, vol. 77, No. 3, New York, NY, US.
Johnson, et al., “The Effect of the Sweetness Inhibitor 2(4-methoxyphenoxy) Propanoic Acid (Sodium Salt) (Na-PMP) on the Taste of Bitter-sweet Stimuli,” Chemical Sense, Aug. 1994, pp. 349-358, vol. 19, No. 4. Oxford, UK.
Temussi, et al., “The history of sweet taste: not exactly a piece of cake”, Journal of Molecular Recognition, 2006, 19: 188-199.
Bönigk, et al., “The Native Rat Olfactory Cyclic Nucleotide-Gated Channel is Composed of Three Distinct Subunits”, The Journal of Neuroscience, vol. 19, No. 136, p. 5332-5347, Jul. 1, 1999.
Alexander, et al., “Altering the Antigenicity of proteins”, Proc. Natl. Acad. Sci. USA, vol. 89, p. 3352-3356, Apr. 1992.
GenBank Accession No. AL139287, clone RP5-89003, Feb. 13, 2000.
Lindemann, “A Taste for Umami”, Nature Neuroscience, vol. 3, No. 2, p. 99-100, Feb. 2000.
Krautwurst et al., “Identification of Ligands for Olfactory Receptor by Functions Expression of a Receptor Library”, Cell, vol. 95, p. 917-926, Dec. 23, 1998.
Bowie, et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”,1990, Science 247: 1306-1310.
Hoon, et al., “Putative Mammalian Taste Receptors : A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity”, Cell, vol. 96, pp. 541-551, Feb 19, 1999—XP-000922524.
Perruccio, et al., Society for Neuroscience Abstracts 26 (1-2) Abstact No. 66.15, 2000.
GenBank Accession No. AA907022, May 19, 1998.
Damak, S., “Detection of Sweet and Umani Taste in the Absence of Taste Receptor T1r3,” vol. 301, pp. 850-853, 2003.
Kinnamon, et al., “Chemosensory Transduction Mechanisms in Taste”, Annu. Rev. Physoil., vol. 54, p. 715-731, 1992.
Extended European Search Report and Opinion for European Application No. 08075748.7 dated Nov. 21, 2008.
European Search Report for European Application No. 08153652.6 dated Jan. 21, 2009.
Jiang, et al., “Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste”, The Journal of Biological Chemistry, vol. 280, No. 15, pp. 15238-15246, Apr. 15, 2005.
Xu, et al., “Different functional roles of T1R subunits in the heteromeric taste receptors”, PNAS, vol. 101, No. 39, pp. 14258-14263, Sep. 28, 2004.
Adler Jon Elliot
Li Xiadong
O'Connell Shawn
Staszewski Lena
Zozulya Sergey
Hunton & Williams LLP
Senomyx Inc.
Ulm John D
LandOfFree
Chimeric T1R1 taste receptor encoding nucleic acid sequences... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric T1R1 taste receptor encoding nucleic acid sequences..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric T1R1 taste receptor encoding nucleic acid sequences... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4154557