Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2002-01-04
2008-09-16
Campell, Bruce (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
active
07425335
ABSTRACT:
A vaccine composition for humans and animals against Japanese encephalitis virus infection is a composition which comprises a chimeric synthetic peptide selected from envelope glycoprotein consisting of amino acids Egp 149-SENHGNYSAQVGASQ-163 (SEQ ID NO:1) AND Egp 429-SIGGVFNSIGKAVHQVFG-446 (SEQ ID NO:2) of Japanese encephalitis virus envelope glycoprotein, present in an amount sufficient to induce protective immunity against Japanese encephalitis virus infection.
REFERENCES:
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Fields Virology, 4th edition, Lippincott Williams & Wilkins, 2001, pp. 437-438.
Saini et al. A Japanese Encephalitis Virus Peptide Present on Johnson Grass Mosaic Virus-Like Particles Induces Virus-Neutralizing Antibodies and Protects Mice against Lethal Challenge. Journal of Virology, Mar. 2003; 77(6): 3487-3494.
Kutubuddin, M. et al., “Analysis of computer-predicted antibody inducing epitope on Japanese encephalitis virus”, Acta Virol., (Engl. Ed), (1993) 37 (6), pp. 417-428, abstract.
Roehring, J.T. et al., “Enhancement of the antibody response to flavivirus B-cell epitopes by using homologous or heterologous T-cell epitopes”, J. Virol. (1992), 66(6), pp. 3385-3390, abstract.
Dewasthaly S. S.
Gore M. M.
Kolaskar Ashok
Kulkarani-Kale Urmila D.
Sawant Sangeeta
Axelrod Nancy J.
Campell Bruce
Le Emily M.
National Institute of Virology
The Secretary Department of Biotechnology
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