Chimeric receptors as inhibitors of vascular endothelial growth

Details Chimeric receptors as inhibitors of vascular endothelial growth Chimeric receptors as inhibitors of vascular endothelial growth

1997-06-13

1999-09-14

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530350, 536 231, 536 234, 4353201, 435325, 435369, 4352523, 43525411, C07K 1471, C12N 1511, C12N 510

Patent

active

059521996

ABSTRACT:
The present invention is directed to novel VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1, FLT4, and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.

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