Chimeric receptor genes and cells transformed therewith

Details Chimeric receptor genes and cells transformed therewith Chimeric receptor genes and cells transformed therewith

1993-07-02

2010-06-22

Wehbe, Anne Marie S (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S325000

Reexamination Certificate

active

07741465

ABSTRACT:
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.

REFERENCES:
patent: 5266478 (1993-11-01), Chang et al.
patent: 5359046 (1994-10-01), Capon et al.
patent: 5906936 (1999-05-01), Eshhar et al.
patent: 5912172 (1999-06-01), Eshhar et al.
patent: 6407221 (2002-06-01), Capon et al.
patent: 0180878 (1986-05-01), None
patent: 0300793 (1989-01-01), None
patent: 0 340 793 (1989-11-01), None
patent: 8601533 (1986-03-01), None
patent: 8809344 (1988-12-01), None
patent: 9210591 (1992-06-01), None
patent: 9215322 (1992-09-01), None
Bed et al Science 242: 423, 1988.
Gross et al PNAS 86: 10024, 1989.
Esther et al Br. J. Cancer 62: 27-29, 1990.
Romeo et al Cell 64: 1037, 1991.
Gross et al, Development and study of chimeric Immunoglobulin/T cell receptor molecules as functional receptors that endow T cells with antibody-type specificity. PH.D. Thesis presented to the Feinberg Graduate School, The Wiezmann Institute of Science, Rehovot, Israel, 1990.
Liou et al (J Immunol. 143:3967-3975, 1989.
Hatakeyama et al (J Exp. Med. 166:362-375, 1987.
Bird et al, Single chain antibody varaible regions. TIBTECH 9:(4):132-137, 1991.
Van de Vijver, M.J., et al., “Neu-Protein Overexpression in Breast Cancer”,New England J. of Med.,vol. 319, No. 19, Nov. 10, 1988, pp. 1239-1245.
Vivier, E., et al., “Structural Similarity Between Fc Receptors and T Cell Receptors”,J. of Immunol.,vol. 147, No. 12, Dec. 15, 1991, pp. 4263-4270.
Walsh, C.M., et al., “The Role of the Fas Lytic Pathway in a Perforin-Less CTL Hybridoma”,J. of Immunol.,vol. 153, 1994, pp. 2506-2514.
Weaver, C.T., et al., “The Costimulatory Function of Antigen-Presenting Cells”,Immunology Today,vol. 11, No. 2, 1990, pp. 49-54.
Weiss, A., et al., “Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation”,Advances in Immunology,vol. 41, 1987, pp. 1-38.
Weiss, A., et al., “Signal Transduction by Lymphocyte Antigen Receptors”,Cell,vol. 76, Jan. 28, 1994, pp. 263-274.
Weissman, A.M., et al., “Role of the Zeta Chain in the Expression of the T Cell Antigen Receptor: Genetic Reconstruction Studies”,The EMBO Journal,vol. 8, No. 12, 1989, pp. 3651-3656.
Wirthmueller, U., et al., “Signal Transduction by Fc RIII (CD16) is Mediated Through the Chain”,J. Exp. Med.,vol. 175, May 1992, pp. 1381-1390.
Yague, J., et al., “The T Cell Receptor: The α and β Chains Define Idiotype, and Antigen and MHC Specificity”,Cell,vol. 42, Aug. 1985, pp. 81-87.
Bacus, S.S., et al., “Tumor-Inhibitory Monoclonal Antibodies to the HER-2/Neu Receptor Induce Differentiation of Human Breast Cancer Cells”,Cancer Research,vol. 52, May 1, 1992, pp. 2580-2589.
Benhamou, M., et al., “Protein-Tyrosine Kinase p72sykin High Affinity IgE Receptor Signaling”,J. of Biol. Chem.,vol. 268, No. 31, Nov. 5, 1993, pp. 23318-23324.
Gauen, L.K.T., et al., “Interactions of p59fynand ZAP-70 with T-Cell Receptor Activation Motifs: Defining the Nature of a Signalling Motif”,Mol. and Cell. Biol.,vol. 14, No. 6, Jun. 1994, pp. 3729-3741.
Hutchcroft, J.E., et al., “Association of the 72-kDa Protein-Tyrosine Kinase PTK72 with the B Cell Antigen Receptor”,J. of Biol. Chem.,vol. 267, No. 12, Apr. 25, 1992, pp. 8613-8619.
Kolanus, W., et al., “T Cell Activation by Clustered Tyrosine Kinases”,Cell,vol. 74, Jul. 16, 1993, pp. 171-183.
Law, C-L., et al., “Molecular Cloning of Human Syk”,J. of Biol. Chem.,vol. 269, No. 16, Apr. 22, 1994, pp. 12310-12319.
Letourneur, F., et al., “T-Cell and Basophil Activation Through the Cytoplasmic Tail of T-Cell-Receptor Family Proteins”,PNAS,vol. 88, Oct. 1991, pp. 8905-8909.
Schwarzbaum, S., et al., “Mapping of Murine IgE Epitopes Involved in IgE-FcEReceptor Interactions”,Eur. J. Immunol.,vol. 19, 1989, pp. 1015-1023.
Shindo, T., et al., “Down-Regulation of KOLT-2 Antigen (CD28) by Interleukin 2; Role of IL-2R (p70)”,Immunology,vol. 71, 1990, pp. 63-69.
Taniguchi, T., et al., “Molecular Cloning of a Porcine Gene syk That Encodes to 72-kDa Protein-Tyrosine Kinase Showing High Susceptibility to Proteolysis”,J. of Biol. Chem.,vol. 266, No. 24, Aug. 25, 1991, pp. 15790-15796.
Culver, K., et al., “Lymphocytes as Cellular Vehicles for Gene Therapy in Mouse and Man”,PNAS,vol. 88, Apr. 1991, pp. 3155-3159.
Rosenberg, S.A., “Adoptive Immunotherapy for Cancer”,Scientific American,May 1990, pp. 62-69.
Anasetti, C. et al., “Induction of Specific Nonresponsiveness in Unprimed Human T Cells by Anti-CD3 Antibody and Alloantigen”,J. Exp. Med.,vol. 172, Dec. 1990, pp. 1691-1700.
Aruffo, A. et al., “Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system”,Proc. Watl. Acad. Sci.,vol. 84, Dec. 1987, pp. 8573-8577.
Bach, N. et al., “Specific lysis of tumor cells by an NK-like cell line transfected with chimeric receptor genes”,Department of Chemical Immunology,1995, pp. 1-26.
Baroja, M. et al., “The Anti-T Cell Monoclonal Antibodyt 9.3 (Anti-CD28) Provides a Helper Signal and Bypasses the Need for Accessory Cells in T Cell Activation woth Immobilized Anti-CD3 and Mitogens”, vol. 120, 1989, pp. 205-217.
Bauer, A. et al., “Differential signal transduction via T-cell receptor CD3zeta2, CD3zeta-eta, and CD3eta2isoforms”,Proc. Natl. Acad. Sci.,vol. 88, May 1991, pp. 3842-3846.
Becker, M. et al., “Expression of a Hybrid Immunoglobin-T Cell Receptor Protein in Transgenic Mice”,Cell,vol. 58, Sep. 1989, pp. 911-921.
Berke, G. “Lymphocyte-triggered internal target disintegration”,Immunology Today,vol. 12, No. 11, 1991, pp. 396-399.
Bolen, J. “Signal Transduction by the SRC Family of Tyrosine Protein Kinases in Hemapoietic Cells”,Cell Growth&Differentiation,vol. 2, Aug. 1991, pp. 409-414.
Bowen, M. et al., “Functional Effects of CD30 on a Large Granular Lymphoma Cell Line, YT”,The Journal of Immunology,vol. 151, No. 11, Dec. 1993, pp. 5896-5906.
Burkhardt, A. et al., “Ig-alpha and Ig-beta Are Functioinally Homologous to the Signaling Proteins of the T-Cell Receptor”,Molecular and Cellular Biology,vol. 14, No. 2, Feb. 1994, pp. 1095-1103.
Celis, E. et al., “Binding of T cell receptor to major histocompatibility complex class II-peptide complexes at the single-cell level results in the induction of antigen unresponsiveness (anergy)”Eur. J. Immunology,vol. 22, 1992, pp. 3127-3134.
Chan, A., et al., “The Zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associate with ZAP-70, a 70-kDa tyrosine phosphoprotein”,Immunology,vol. 88, Oct. 1991, pp. 9166-9170.
Chan, A. et al., “ZAP-70: A 70 kd Protein-Tyrosine Kinase that Associates with the TCR Zeta Chain”,Cell,vol. 71, Nov. 1992, pp. 649-662.
Chen, L. et al., “Costimulation of Antitumor Immunity by the B7 Counterreceptor for the T Lymphocyte Molecules CD28 and CTLA-4”,Cell,vol. 71, Dec. 1992, pp. 1093-1102.
Ciccone, E. et al., “Specific functions of human NK cells”,Immunology Letters,vol. 31, 1992, pp. 99-104.
Cline, J. “Gene therapy: current status and future directions”, vol. 116, 1986, pp. 1459-1464.
Couture, C. et al., “p56lck-independent activation and tyrosine phosphorylation of p72sykby T-cell antigen receptor/CD3 St

Affiliated with

Also associated with

Rating

Chimeric receptor genes and cells transformed therewith does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric receptor genes and cells transformed therewith, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric receptor genes and cells transformed therewith will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4246945