Chimeric proteins with phosphatidylserine binding domains

Details Chimeric proteins with phosphatidylserine binding domains Chimeric proteins with phosphatidylserine binding domains

2008-06-11

2010-10-05

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07807644

ABSTRACT:
Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and/or inhibit cancer by targeting sTF to specific receptors such as phosphatidylserine (PS) on activated cells. These chimeric proteins are useful in treating patients with excessive bleeding due to inborn problems, drug therapy, trauma or surgery and/or as an anti-cancer therapy, for example by causing blood vessels feeding cancers to become clotted, thereby preventing adequate flow of blood to a tumor, which in turn will lead to tumor inhibition and death or may be used in a therapy to cause clotting within blood vessels that pose a threat in the subject in non-cancerous conditions.

REFERENCES:
patent: 5296467 (1994-03-01), Reutelingsperger
patent: 5298599 (1994-03-01), Rezaie et al.
patent: 6132729 (2000-10-01), Thorpe et al.
patent: 6156321 (2000-12-01), Thorpe et al.
patent: 6194214 (2001-02-01), Kraus
patent: 6312694 (2001-11-01), Thorpe et al.
patent: 6406693 (2002-06-01), Thorpe et al.
patent: 6491894 (2002-12-01), Ruoslahti et al.
patent: 6528481 (2003-03-01), Burg et al.
patent: 6576239 (2003-06-01), Ruoslahti et al.
patent: 6610651 (2003-08-01), Ruoslahti et al.
patent: 6749853 (2004-06-01), Thorpe et al.
patent: 6818213 (2004-11-01), Thorpe et al.
patent: 6933281 (2005-08-01), Ruoslahti et al.
patent: 6962903 (2005-11-01), Allison
patent: 7252959 (2007-08-01), Rand
patent: 7393833 (2008-07-01), Lind et al.
patent: WO 2000/02587 (2000-01-01), None
Huang et al., “A soluble tissue factor-annexin V chimeric protein has both procoagulant and anticoagulant properties”,Blood, vol. 107, No. 3, pp. 980-986 (Feb. 1, 2006).
Paborsky et al., “Lipid Association, but Not the Transmembrane Domain, Is Required for Tissue Factor Activity”,The Journal of Biological Chemistry, vol. 266, No. 32, pp. 21911-21916 (Nov. 15, 1991).
Ida et al., “Human Annexin V Binds to Sulfatide: Contribution to Regulation of Blood Coagulation”,Journal of Biochemistry, (2004), vol. 135, No. 5, pp. 583-588, [ http://jb.oxfordjournals.org ] (3 pages).
Rand et al., “Human Monoclonal Antiphospholipid Antibodies Disrupt the Annexin A5 Anticoagulant Crystal Shield on Phospholipid Bilayers”,American Journal of Pathology, vol. 163, No. 3 (Sep. 2003) pp. 1193-1200.
Thiagarajan et al., “Inhibition of Arterial Thrombosis by Recombinant Annexin V in a Rabbit Carotid Artery Injury Model”,Circulation, (1997) vol. 96, pp. 2339-2347 [ http://www.circ.ahajournals.org ] (23 pages).
Wang et al., “Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells”,Am. J. Physiol. Cell. Physiol. (2002) vol. 282, pp. C1313-C1321 [ http://ajpcell.physiology.org ] (14 pages).
“Annexin A5” [ http://en.wikipedia.org/wiki/Annexin—A5 ] (4 pages), Dec. 2007.
Abnova® Corporation, [ http://www.abnova.com. ] (2 pages), Dec. 2007.
Chen et al., “Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants”, Blood, (May 15, 2005), vol. 105, No. 10, pp. 3902-3909, [http://bloodjournal.hematologylibrary.org] (15 pages).

Affiliated with

Also associated with

Rating

Chimeric proteins with phosphatidylserine binding domains does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric proteins with phosphatidylserine binding domains, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric proteins with phosphatidylserine binding domains will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4156814