Chimeric proteins with natriuretic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C435S069700, C514S021300, C530S317000, C530S323000

Reexamination Certificate

active

08058242

ABSTRACT:
The present invention discloses proteinaceous compounds that comprise at least a biologically active portion of a taipan natriuretic peptide (TNP) or a variant or derivative thereof. The invention also relates to the use of these compounds in methods for stimulating vasodilation, natriuresis, diuresis, renin-suppression, bactericidal activity, weight-loss or bone growth in a mammalian host. In specific embodiments, the compounds are useful in the treatment of congestive heart failure.

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PubMed Protein ID P83231 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83230 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83225 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83226 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83224 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83228 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83229 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P83227 Venom natriuretic peptide OxsSNPc, available online Sep. 15, 2003.
PubMed Protein ID P22642 Ventricular natriuretic peptide, available online Aug. 1, 1991.
PubMed Protein ID 046541 Brain natriuretic peptide precursor, available online Jun. 15, 2002.
PubMed Protein ID P07634 Brain natriuretic peptide precursor, available online Nov. 1, 1991.
PubMed Protein ID P16859 Brain natriuretic peptide precursor, available online Nov. 1, 1990.
PubMed Protein ID P13204 Brain natriuretic peptide precursor, available online Dec. 1, 1992.
PubMed Protein ID P56283 C-type natriuretic peptide precursor, available online Feb. 1, 1998.
PubMed Protein ID P55207 C-type natriuretic peptide precursor, available online Oct. 1, 1996.
PubMed Protein ID P18104 C-type natriuretic peptide precursor, available online Mar. 1, 1992.
PubMed Protein ID Q61839 C-type natriuretic peptide precursor, available online Nov. 1, 1997.
PubMed Protein ID P23582 C-type natriuretic peptide precursor, available online Dec. 1, 1992.
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Luis Bolaños Cea, “Natriuretic Peptide Family: New Aspects”,Curr. Med. Chem. 2005, 3: 87-98.

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