Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-06-06
1998-10-06
Walsh, Stephen
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435325, 435366, 4353201, 435 691, 530350, 514 12, C07K 14705, C07K 1479, C12N 510, C12N 1512
Patent
active
058177892
ABSTRACT:
Chimeric proteins, which bind a cell surface receptors, useful in transporting a selected substance present in extracellular fluids, such as blood or lymph, into cells; quantitative assays for the selected substance using chimeric proteins; DNA encoding the chimeric proteins; plasmids which contain DNA encoding the chimeric proteins; mammalian cells, modified to contain DNA encoding the chimeric proteins, which express and, optionally, secrete the chimeric proteins; a method of producing the chimeric proteins; a method of isolating the chimeric proteins; a method of using the chimeric proteins to assay the selected substance; and a method of reducing extracellular levels of the selected substance through administration of the chimeric protein, which results in transport of the selected substance into cells.
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Concino Michael F.
Heartlein Michael W.
Lemontt Jeffrey F.
Kaufmann Claire M.
Transkaryotic Therapies Inc.
Walsh Stephen
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