Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-08-05
1996-12-31
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 696, 435 697, 4352401, 4352523, 43525411, 4352542, 43525424, 43525422, 43525423, 536 234, 530350, 530395, 514 2, 514 12, C12N 1515, C12N 1563, A61K 3800, C07K 1481, C07K 14745, C12P 2102, A61K 3857, A61K 3836
Patent
active
055893597
ABSTRACT:
Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
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Creasey Abla A.
Innis Michael A.
Blackburn Robert P.
Bugaisky Gabriele E.
Chiron Corporation
Green Grant D.
Savereide Paul B.
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