Chimeric protein which confers protection against parainfluenza

Details Chimeric protein which confers protection against parainfluenza Chimeric protein which confers protection against parainfluenza

1997-05-07

2000-01-25

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

42419611, 4241991, 4242021, 4242041, 4242111, 530350, 530403, A61K 3900, A61K 39385, A61K 3912, C07K 100

Patent

active

060175397

ABSTRACT:
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.

REFERENCES:
patent: 4578269 (1986-03-01), Morein
patent: 4722898 (1988-02-01), Paoletti et al.
patent: 4866034 (1989-09-01), Ribi
patent: 4879213 (1989-11-01), Fox et al.
patent: 4950480 (1990-08-01), Barber et al.
patent: 5098998 (1992-03-01), Mekolanos et al.
patent: 5110587 (1992-05-01), Paoletti et al.
Am. J. Epidemiology 89, 1969, p. 405-421, Kapikian et al.
J. Inf. Dis. 145, 1982, p. 311-319, Belsche et al.
Ray et al, (1989) Virus Research, 12:169-180.
Coelingh et al, (1987) Virology 160;465-472.
Wathen et al, (1989) J. Of Inf. Dis. 159:255-263.
Spriggs et al, (1987), J. Virol. 61:3416-3423.
Stott et al, (1987) J. Virol. 61:3855-3861.
Wathen et al (1989) J. Gen. Virol. 70:2625-2635.
Wathen et al (1989) J. Gen. Virol. 70:2637-2644.
Conners et al (1992) Vaccine 10:475-484.
Perkus et al (1989) J. Virology 63:3829-3836.
Goebel et al, (1990) Virology 179:247-266.
Perkus et al (1990) Virology 179:276-286.
Goebel et al (1990) Virology 179:517-563.
Targaglia et al (1992) Virology 188:217-232.
Piccini et al (1987) Methods in Enzymolgy, 153:545-563.
Taylor et al, (1990) J. Virology 64:1441-1450.
Collins et al (1990) J. Virology 64:4007-4012.
Vijaya et al -Mol. Cell. Biol. vol. 8: No 4 (1988) pp. 1709-1714.
Roy et al, J. Infec. Dis. 157 C47:648-57 (1988).
Stover et al, Nature 351:456-460 (1991).
Olmstead et al PNAS 83, 7462-7466 (1986).
Chanock et al, Pediatrics vol. 90, No. 1, Jul. 1992, pp. 137-143.
Murphy et al, Experimental Lung Research 2:97-109 (1981).
Porter et al, J. Of Virology, Jan. 1991 -vol. 65:No. 1, pp. 103-111.
Prince et al, Am. J. Of Pathology, vol. 93, No. 3; pp. 771-783, 1978.
Prince et al, J. Of Virology 57:721-728, Mar. 1986.
Tizard, I. "An Introduction to Veterinary Immunology", -2.sup.nd Edition -published by W.B. Saunders Company (1982), pp. 123-124.
Hall et al, Science 265:1393-1399 (1994).
Bowie et al, Science 247: 1306-1310 (1990).
Kumar et al, PNAS 87:1337-1341 (1990).
Lazar et al, Molecular and Cellular Biology, 8(3):1247-52 (1988).
Burgess et al, Journal of Cell Biology 111:2129-38 (1990).
Hendry et al (J. Gen. Virol. vol. 64(8) pp. 3833-3843), Aug. 1985.
Coelingh et al (J. of Virology vol. 63(9) pp. 3755-3760), Sep. 1989.

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