Chimeric protein tyrosine kinases

Details Chimeric protein tyrosine kinases Chimeric protein tyrosine kinases

1995-06-02

1996-04-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 435 697, 4352402, 530350, 536 221, 536 231, 536 232, 536 234, 536 235, C12N 912, C12N 500, C12P 2106, C07H 1900

Patent

active

055040004

ABSTRACT:
The present invention provides chimeric proteins containing extracellular and transmembrane domains of CD4 and protein tyrosine kinases of the src family. Also provided are DNA molecules encoding the proteins of the present invention and cells containing such DNA molecules. The proteins and cells of the present invention may be employed in methods for identifying drugs that block T cell activation and for identifying low level self-antigens.

REFERENCES:
Glaichenhaus et al. "Requirement for Association of p56 .sup.lck . . . " Cell 64:511-520 (1991).
Turner et al. "Unteraction of the Unique N-Terminal . . . " Cell 60:755-765 (1990).

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