Chimeric protein comprising an RTX-family cytotoxin and interfer

Details Chimeric protein comprising an RTX-family cytotoxin and interfer Chimeric protein comprising an RTX-family cytotoxin and interfer

1993-12-20

1997-01-14

Walsh, Stephen G.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 695, 435 697, 530351, 530825, 4241921, 42419511, 42419711, 424 851, C12N 1519, A61K 39102

Patent

active

055941079

ABSTRACT:
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

REFERENCES:
patent: 3328252 (1967-06-01), Mora
patent: 4167560 (1979-09-01), Wohler, Jr.
patent: 4171354 (1979-10-01), Smith
patent: 4328210 (1982-05-01), Kucera
patent: 4346074 (1982-08-01), Gilmour et al.
patent: 4366246 (1982-12-01), Riggs
patent: 4675382 (1987-06-01), Murphy
patent: 4704362 (1987-11-01), Itakura et al.
patent: 4818769 (1989-04-01), Nunberg et al.
patent: 4933299 (1990-06-01), Greenfield
patent: 4935233 (1990-06-01), Bell et al.
patent: 4957739 (1990-09-01), Berget et al.
patent: 5028423 (1991-07-01), Prickett
patent: 5071761 (1991-12-01), Meyer et al.
patent: 5095096 (1992-03-01), Miki et al.
patent: 5108910 (1992-04-01), Curtis et al.
patent: 5114711 (1992-05-01), Bell et al.
Cho et al., Can. J. Vet. Res. (1986) 50:27-31.
Cho et al., Can. J. Comp. Med. (1984) 48:151-155.
Conlon et al., Infect. Immun. (1991) 59(2):587-591.
Czarniecki et al., J. Interferon Res. (1986) 6:29-37.
Donanche et al., J. Gen. Microbiol. (1984) 130:1209-1216.
Gentry et al., Vet. Immunology and Immunopathology (1985) 9:239-250.
Highlander et al., DNA (1989) 8:15-28.
Himmel et al., Am. J. Vet. Res. (1982) 43:764-767.
Lally et al., Biochem Biophys. Res. Comm. (1989) 159(1):256-262.
Lawman et al., Comprehensive Biotech, First Supplement, Animal Biotechnology (1989) Pergamon Press, London, pp. 63-106.
Lessley et al., Veterinary Immunology and Immunopathology (1985) 10:279-296.
Lo et al., Infect. Immun. (1985) 50:667-671.
Lorberboum-Galski et al., Proc. Natl. Acad. Sci. USA (1988) 85:1922-1926.
Martin et al., Can. J. Comp. Med. (1980) 44:1-10.
Shewen et al., Am. J. Vet. Res. (1983) 44:715-719.
Shewen et al., Can. J. Vet. Res. (1988) 52:30-36.
Strathdee et al., J. Bacteriol. (1989) 171(2):916-928.
Strathdee et al., Infect. Immun. (1987) 55(12):3233-3236.
Williams et al., Protein Eng. (1987) 1(6):493-498.
Yates Can. J. Comp. Med. (1982) 46:225-263.
R. A. Welch, Pore-forming cytolysins of Gram-negative bacteria, Molecular Microbiology (1991), 5(3):521-528.

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