Chimeric polypeptide comprising the fragment B of shiga...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...

Reexamination Certificate

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C530S300000, C536S023100

Reexamination Certificate

active

07488809

ABSTRACT:
The invention pertains to methods for using chimeric polypeptides of the formula:in-line-formulae description="In-line Formulae" end="lead"?B—Xin-line-formulae description="In-line Formulae" end="tail"?wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. Compositions for therapeutic use comprising the polypeptide B—X are also included.

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